Evidence map›Paper›PMID 33767185›Full record

ReviewNature reviews. Disease primers2021

Tension-type headache.

Sait Ashina, Dimos D Mitsikostas, Mi Ji Lee, Nooshin Yamani, Shuu-Jiun Wang, Roberta Messina, Håkan Ashina, Dawn C Buse, Patricia Pozo-Rosich, Rigmor H Jensen and 2 more

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 112 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 18 pooled it
20.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06155669 nacompletednot on this mapstarted 2023, after this paper: background citation

The Impact of Virtual Reality -Guided Visual and Auditory Therapy on Symptom Severity and Psychological Well-Being in Tension-Type Headache Patients: A Controlled Study

TypeinterventionalSponsorAnkara City Hospital BilkentRan2023 to 2024Enrolled140ConditionsHeadache, Analgesia, Tension-Type HeadacheArmsVirtual Reality
NCT06452628 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effects of Mulligan Mobilizations Versus Active Release Technique on Pain, Range of Motion and Disability in Patients With Tension-Type Headache.

TypeinterventionalSponsorRiphah International UniversityRan2024 to 2024Enrolled33ConditionsTension-Type HeadacheArmsMulligan mobilizations, Active Release Technique, Mulligan mobilizations with active release technique
3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 18 syntheses or guidelines pooled it, 219 citations in OpenAlex.

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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 9 countries.

Sait AshinaBIDMC Comprehensive Headache Center, Department of Neurology and Department of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA. sashina@bidmc.harvard.edu.ORCID 0000-0003-3973-6640
Dimos D MitsikostasFirst Neurology Department, Aeginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Mi Ji LeeDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.ORCID 0000-0003-1364-1969
Nooshin YamaniHeadache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Shuu-Jiun WangDepartment of Neurology, Neurological Institute, Taipei Veterans General Hospital, Brain Research Center, National Yang-Ming University, Taipei, Taiwan.ORCID 0000-0001-5179-5358
Roberta MessinaNeuroimaging Research Unit and Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0003-4421-0432
Håkan AshinaDanish Headache Center, Department of Neurology, University of Copenhagen, Rigshospitalet Glostrup, Glostrup, Denmark.
Dawn C BuseDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Patricia Pozo-RosichHeadache Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Rigmor H JensenDanish Headache Center, Department of Neurology, University of Copenhagen, Rigshospitalet Glostrup, Glostrup, Denmark.ORCID 0000-0001-6433-5887
Hans-Christoph DienerFaculty of Medicine, Institute for Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany.ORCID 0000-0002-6556-8612
Richard B LiptonDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
University of Copenhagen · DKAlbert Einstein College of Medicine · USNational and Kapodistrian University of Athens · GRNational Yang Ming Chiao Tung University · TWSamsung Medical Center · KRTehran University of Medical Sciences · IRUniversitat Autònoma de Barcelona · ESUniversity of Duisburg-Essen · DEVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tension-type headache (TTH) is the most prevalent neurological disorder worldwide and is characterized by recurrent headaches of mild to moderate intensity, bilateral location, pressing or tightening quality, and no aggravation by routine physical activity. Diagnosis is based on headache history and the exclusion of alternative diagnoses, with clinical criteria provided by the International Classification of Headache Disorders, third edition. Although the biological underpinnings remain unresolved, it seems likely that peripheral mechanisms are responsible for the genesis of pain in TTH, whereas central sensitization may be involved in transformation from episodic to chronic TTH. Pharmacological therapy is the mainstay of clinical management and can be divided into acute and preventive treatments. Simple analgesics have evidence-based effectiveness and are widely regarded as first-line medications for the acute treatment of TTH. Preventive treatment should be considered in individuals with frequent episodic and chronic TTH, and if simple analgesics are ineffective, poorly tolerated or contraindicated. Recommended preventive treatments include amitriptyline, venlafaxine and mirtazapine, as well as some selected non-pharmacological therapies. Despite the widespread prevalence and associated disability of TTH, little progress has been made since the early 2000s owing to a lack of attention and resource allocation by scientists, funding bodies and the pharmaceutical industry.

Indexed as

Tension-Type HeadacheAnalgesicsHumansAnalgesics

Identifiers

PMID33767185
OpenAlexW2486147174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.