ArticleThe European respiratory journal2021
A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity.
Article in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
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42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.The American journal of clinical nutrition · 2024Pooled it
- Genome-wide association study of preserved ratio impaired spirometry (PRISm).The European respiratory journal · 2024Pooled it
- Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.Nature genetics · 2023Pooled it
- Assessing causal relationships between gut microbiota and asthma: evidence from two sample Mendelian randomization analysis.Frontiers in immunology · 2023Pooled it
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- Development and validation of risk factors prediction model for hypoxemia in the PACU patients after major abdominal surgery: a retrospective study.Frontiers in medicine · 2026Article
- Common genetic variation influencing the human lung imaging phenotypes.Nature communications · 2025Article
- Characterization of prevalent genetic variants in the Estonian Biobank body-mass index GWAS.Nature communications · 2025Article
- Gene-environment interaction at 17q12-q21 locus and its role in asthma pathogenesis.The European respiratory journal · 2025Article
- Longitudinal study of the influence of obesity, C-reactive protein, and smoking on FEV1 decline in young adulthood.BMC pulmonary medicine · 2025Observational
- Chromosome 21 variants tied to severe asthma exacerbations: A genome-wide association study in a Brazilian population.The journal of allergy and clinical immunology. Global · 2025Article
- Impact of genetic risk and lifestyles on cardiovascular disease-free and total life expectancy: a cohort study.Genome medicine · 2025Article
- The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and preserved ratio impaired spirometry: NHANES 2007-2012.Lipids in health and disease · 2025Article
- Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia.Respirology (Carlton, Vic.) · 2025Observational
- Evaluation of silicosis combined with type 2 diabetes mellitus based on the quantitative CT measured parameters.Quantitative imaging in medicine and surgery · 2025Article
- Relationship between HECTD4 gene variants, obesity, and coffee consumption.European journal of clinical nutrition · 2025Article
- Massively parallel variant-to-function mapping determines functional regulatory variants of non-small cell lung cancer.Nature communications · 2025Article
- Body mass index trajectories may represent modifiable targets in the promotion of respiratory health.The European respiratory journal · 2025Article
- Potential Causal Relationship Between Chronic Obstructive Pulmonary Disease and Diabetes: A Bidirectional Two-Sample Mendelian Randomization Study.International journal of chronic obstructive pulmonary disease · 2025Article
- Associations between body mass index and lung function using Z-scores: a nonlinear relationship and machine learning classification modeling.Frontiers in physiology · 2025Article
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24 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundLung function is a heritable complex phenotype with obesity being one of its important risk factors. However, knowledge of their shared genetic basis is limited. Most genome-wide association studies (GWASs) for lung function have been based on European populations, limiting the generalisability across populations. Large-scale lung function GWASs in other populations are lacking.
methodsWe included 100 285 subjects from the China Kadoorie Biobank (CKB). To identify novel loci for lung function, single-trait GWAS analyses were performed on forced expiratory volume in 1 s (FEV
resultsWe identified nine genome-wide significant novel loci for FEV
conclusionThis large-scale GWAS of lung function identified novel loci and shared genetic aetiology between lung function and obesity. Change in BMI might affect change in lung function differently according to a subject's polygenic background. These findings may open new avenues for the development of molecular-targeted therapies for obesity and lung function improvement.
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