ArticleScience (New York, N.Y.)2021
Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
22.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 167 citations in OpenAlex.
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- Structural basis of regioselective double halogenation of the β-carboline tryptoline by the single-component halogenase AetF.Acta crystallographica. Section D, Structural biology · 2026Article
- Unveiling Putative Functions of Burkholderia pseudomallei K96243 Hypothetical Proteins Via High-Throughput Characterization of Structural Similarities.Interdisciplinary sciences, computational life sciences · 2026Article
- Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery.Natural product reports · 2026Review
- Development and validation of a multiclass LC-MS/MS method for the analysis of cyanotoxins.Analytical and bioanalytical chemistry · 2026Article
- Mining the past for the future: cyanobacterial herbarium specimens for systematics, evolution, and cyanotoxin diversity.Frontiers in microbiology · 2026Review
- Constructing Petroleum-Derived Aryl Hydrocarbon Receptor Related Toxic Source Profiles via Effect-Directed Analysis.Environment & health (Washington, D.C.) · 2025Article
- Combined Effects of Irradiation, Nutrients, and Cyanobacterial Composition on Microcystin Concentration in Chinese Plateau Lakes.Environment & health (Washington, D.C.) · 2025Article
- Halogenation-Guided Chemical Screening Uncovers Cyanobacterin Analogues from the CyanobacteriumJournal of natural products · 2025Article
- Aetokthonotoxin, the Causative Agent of Vacuolar Myelinopathy, Uncouples Oxidative Phosphorylation due to Protonophore Activity.Chemical research in toxicology · 2025Article
- Stress genomics of the toxigenic cyanobacteria: environmental and biotechnological perspectives.World journal of microbiology & biotechnology · 2025Review
- Metagenomic Identification of Brominated Indole Biosynthetic Machinery from Cyanobacteria.Journal of natural products · 2025Article
- Biotransformation of Tire-Derived 6PPD and 6PPD-Q in Soil NematodeEnvironmental science & technology · 2025Article
- Mining for Halogenated Metabolites ofJournal of natural products · 2025Article
- Jaspamide/Jasplakinolide Is Synthesized byJournal of natural products · 2025Article
- Structure and dynamics of Proteus vulgaris tryptophan indole-lyase complexes with l-ethionine and l-alanine.Archives of biochemistry and biophysics · 2025Article
- Single-Enzyme Conversion of Tryptophan to Skatole and Cyanide Expands the Mechanistic Competence of Diiron Oxidases.Journal of the American Chemical Society · 2025Article
- Mechanistic Perspective on C-N and C-S Bond Construction Catalyzed by Cytochrome P450 Enzymes.ACS bio & med chem Au · 2025Review
Corrections and comments
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Authors and funding
21 authors at 8 institutions in 4 countries.
Steffen Breinlinger *Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.ORCID https://orcid.org/0000-0002-8155-814X
Tabitha J Phillips *Warnell School of Forestry and Natural Resources, University of Georgia, Athens, GA, USA.ORCID https://orcid.org/0000-0003-4599-1154
Brigette N HaramWarnell School of Forestry and Natural Resources, University of Georgia, Athens, GA, USA.ORCID https://orcid.org/0000-0001-8933-5613
Jan MarešBiology Centre of the Czech Academy of Sciences, Institute of Hydrobiology, České Budějovice, Czech Republic.ORCID https://orcid.org/0000-0002-5745-7023
José A Martínez YerenaBiology Centre of the Czech Academy of Sciences, Institute of Hydrobiology, České Budějovice, Czech Republic.ORCID https://orcid.org/0000-0002-7523-822X
Pavel HrouzekCentre Algatech, Institute of Microbiology of the Czech Academy of Sciences, Třeboň, Czech Republic.
Roman SobotkaCentre Algatech, Institute of Microbiology of the Czech Academy of Sciences, Třeboň, Czech Republic.ORCID https://orcid.org/0000-0001-5909-3879
W Matthew HendersonOffice of Research and Development, Center for Environmental Measurement and Modeling, U.S. Environmental Protection Agency, Athens, GA, USA.ORCID https://orcid.org/0000-0002-2800-8536
Peter SchmiederLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID https://orcid.org/0000-0001-9968-9327
Susan M WilliamsDepartment of Population Health, Poultry Diagnostic and Research Center, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
James D LauderdaleDepartment of Cellular Biology, University of Georgia, Athens, GA, USA.ORCID https://orcid.org/0000-0001-7503-0528
H Dayton WildeHorticulture Department, University of Georgia, Athens, GA, USA.ORCID https://orcid.org/0000-0002-4846-9831
Wesley GerrinWarnell School of Forestry and Natural Resources, University of Georgia, Athens, GA, USA.ORCID https://orcid.org/0000-0002-1725-9372
Andreja KustBiology Centre of the Czech Academy of Sciences, Institute of Hydrobiology, České Budějovice, Czech Republic.ORCID https://orcid.org/0000-0003-4016-6454
John W WashingtonOffice of Research and Development, Center for Environmental Measurement and Modeling, U.S. Environmental Protection Agency, Athens, GA, USA.ORCID https://orcid.org/0000-0001-9952-600X
Christoph WagnerInstitute of Chemistry, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.ORCID https://orcid.org/0000-0001-6141-351X
Benedikt GeierMax Planck Institute for Marine Microbiology (MPIMM), Bremen, Germany.ORCID https://orcid.org/0000-0002-2942-2624
Manuel LiebekeMax Planck Institute for Marine Microbiology (MPIMM), Bremen, Germany.ORCID https://orcid.org/0000-0002-2339-1409
Heike EnkeCyano Biotech GmbH, Berlin, Germany.ORCID https://orcid.org/0000-0003-1043-039X
Timo H J Niedermeyer *Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany. swilde@uga.edu timo.niedermeyer@pharmazie.uni-halle.de.ORCID https://orcid.org/0000-0003-1779-7899
Susan B Wilde *Warnell School of Forestry and Natural Resources, University of Georgia, Athens, GA, USA. swilde@uga.edu timo.niedermeyer@pharmazie.uni-halle.de.ORCID https://orcid.org/0000-0002-5388-9582
University of Georgia · USCzech Academy of Sciences · CZMartin Luther University Halle-Wittenberg · DEEnvironmental Protection Agency · IEMax Planck Institute for Marine Microbiology · DEUniversity of South Bohemia in České Budějovice · CZCyano Biotech (Germany) · DELeibniz-Forschungsinstitut für Molekulare Pharmakologie · DE
Funding
CRCNS: Quantum of Network Dysfunction in Epilepsy-Understanding the Inhibitory RestraintR01NS090645 · NINDS · UNIVERSITY OF GEORGIA · PI BARABAN, SCOTT C, KNER, PETER ALEXANDER · 2014 to 2018
$1.6MIntramural EPA EPA999999NINDS NIH HHS R01 NS090645
Abstract
Vacuolar myelinopathy is a fatal neurological disease that was initially discovered during a mysterious mass mortality of bald eagles in Arkansas in the United States. The cause of this wildlife disease has eluded scientists for decades while its occurrence has continued to spread throughout freshwater reservoirs in the southeastern United States. Recent studies have demonstrated that vacuolar myelinopathy is induced by consumption of the epiphytic cyanobacterial species
Indexed as
CyanobacteriaEaglesAnimalsBacterial ToxinsBird DiseasesBromidesBromineCaenorhabditis elegansChickensDemyelinating DiseasesGenes, BacterialHydrocharitaceaeIndole AlkaloidsLethal Dose 50Multigene FamilyNeurotoxinsBacterial ToxinsBromidesBromineIndole AlkaloidsNeurotoxinsTryptophan
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.