Evidence map›Paper›PMID 33766775›Full record

ReviewProgress in retinal and eye research2021

Artificial intelligence in OCT angiography.

Tristan T Hormel, Thomas S Hwang, Steven T Bailey, David J Wilson, David Huang, Yali Jia

Abstract readReview
In one paragraph

Review in Progress in retinal and eye research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Clinically Explainable Disease Diagnosis Based on Biomarker Activation Map.IEEE transactions on bio-medical engineering · 2026
    Article
  6. Article
  7. Microglial polarization in retinal neovascularization: Friend or foe?Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Hybrid attention-based deep learning for multi-label ophthalmic disease detection on fundus images.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
  13. Article
  14. Widefield OCT angiography.Progress in retinal and eye research · 2025
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Advances in OCT Angiography.Translational vision science & technology · 2025
    Review
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tristan T HormelCasey Eye Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
Thomas S HwangCasey Eye Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
Steven T BaileyCasey Eye Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
David J WilsonCasey Eye Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
David HuangCasey Eye Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
Yali JiaCasey Eye Institute, Oregon Health & Science University, Portland, OR, 97239, USA; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, 97239, USA. Electronic address: jiaya@ohsu.edu.

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kate E Keller · 1995 to 2026
$19.4M
Functional and Structural Optical Coherence Tomography for GlaucomaR01EY023285 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI David Huang · 2013 to 2026
$8.8M
OCT Angiography for Neovascular Age-related Macular DegenerationR01EY024544 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Steven T Bailey, Yali Jia · 2014 to 2026
$6.2M
OCTA Precursors of Vision-Threatening Complications of Diabetic RetinopathyR01EY035410 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Thomas Hwang, Yali Jia · 2023 to 2026
$2.5M
Translational Vision Science Research at Oregon Health & Science UniversityT32EY023211 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Yali Jia, Kate E Keller · 2013 to 2026
$2.4M
Wide-field and projection-resolved optical coherence tomography angiography in diabetic retinopathyR01EY027833 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HWANG, THOMAS, JIA, YALI · 2017 to 2020
$1.8M
Visible-light OCT angiography, velocimetry, and oximetry for characterizing retinal vascular alterations in glaucomaR01EY031394 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI JIA, YALI, MORRISON, JOHN C · 2020 to 2022
$1.6M
NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY023285NEI NIH HHS R01 EY024544NEI NIH HHS R01 EY027833NEI NIH HHS R01 EY031394NEI NIH HHS R01 EY035410NEI NIH HHS T32 EY023211
6 · The paper itself

Abstract

Optical coherence tomographic angiography (OCTA) is a non-invasive imaging modality that provides three-dimensional, information-rich vascular images. With numerous studies demonstrating unique capabilities in biomarker quantification, diagnosis, and monitoring, OCTA technology has seen rapid adoption in research and clinical settings. The value of OCTA imaging is significantly enhanced by image analysis tools that provide rapid and accurate quantification of vascular features and pathology. Today, the most powerful image analysis methods are based on artificial intelligence (AI). While AI encompasses a large variety of techniques, machine-learning-based, and especially deep-learning-based, image analysis provides accurate measurements in a variety of contexts, including different diseases and regions of the eye. Here, we discuss the principles of both OCTA and AI that make their combination capable of answering new questions. We also review contemporary applications of AI in OCTA, which include accurate detection of pathologies such as choroidal neovascularization, precise quantification of retinal perfusion, and reliable disease diagnosis.

Indexed as

Artificial IntelligenceTomography, Optical CoherenceFluorescein AngiographyHumansRetinaRetinal VesselsArtificial intelligenceDeep learningImage analysisOCT Angiography

Identifiers

PMID33766775
PMCPMC8455727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.