ArticleGene2021
SARS-CoV-2 variants lacking ORF8 occurred in farmed mink and pangolin.
Article in Gene, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Diversity and evolutionary history of endogenous retroviruses in the genome ofMicrobiology spectrum · 2025Article
- SARS-CoV-2 bioaerosol transmission in experimentally infected American mink.Scientific reports · 2025Article
- "Outlaw" mutations in quasispecies of SARS-CoV-2 inhibit replication.Emerging microbes & infections · 2024Article
- Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution.Nature communications · 2024Article
- Assessing the Potential Role of Cats (Pathogens (Basel, Switzerland) · 2023Article
- Household Transmission of SARS-CoV-2 from Humans to Pets, Washington and Idaho, USA.Emerging infectious diseases · 2022Article
- SARS-CoV-2 accessory protein ORF8 is secreted extracellularly as a glycoprotein homodimer.The Journal of biological chemistry · 2022Article
- Household transmission of SARS-CoV-2 from humans to pets in Washington and Idaho: burden and risk factors.bioRxiv : the preprint server for biology · 2022Article
- Coronavirus Infection and Cholesterol Metabolism.Frontiers in immunology · 2022Review
- The emergence, dynamics and significance of SARS-CoV-2 variants.New microbes and new infections · 2022Article
- SARS-CoV-2 in animals: potential for unknown reservoir hosts and public health implications.The veterinary quarterly · 2021Review
- Emerging SARS-CoV-2 variants: impact on vaccine efficacy and neutralizing antibodies.Human vaccines & immunotherapeutics · 2021Article
- SARS-CoV2 spike protein gene variants with N501T and G142D mutation-dominated infections in mink in the United States.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SARS-CoV-2 Variant of Concern 202012/01 (VOC-202012/01) is rapidly spreading worldwide owing to its substantial transmission advantage. The variant has changes in critical sites of the spike protein with potential biological significance. Moreover, VOC-202012/01 has a mutation that inactivates the ORF8 protein, whose absence can change the clinical features of the infection. Why VOC-202012/01 is more transmissible remains unclear, but spike mutations and ORF8 inactivation stand out by their known phenotypic effects. Here I show that variants combining relevant spike mutations and the absence of ORF8 occurred in SARS-CoV-2 and related viruses circulating in other host species. A truncated ORF8 (Q23stop) occurred in a SARS-CoV-2-related virus from a pangolin seized in China in 2017, also with several mutations in critical spike sites. Strikingly, I found that variants without ORF8 (E19stop) and with the N501T spike mutation circulated in farmed mink and humans from Denmark. Although with differences to VOC-202012/01, the identification of these variants highlights the danger of having reservoirs of SARS-CoV-2 and related viruses where more transmissible variants may occur and spill over to humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.