Evidence map›Paper›PMID 33766558›Full record

ArticleThe Journal of biological chemistry

Calmodulin influences MAPK signaling by binding KSR1.

Swetha Parvathaneni, Zhigang Li, David B Sacks

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Imaging the Raf-MEK-ERK Signaling Cascade in Living Cells.International journal of molecular sciences · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Calcium channel blockers potentiate gemcitabine chemotherapy  in pancreatic cancer.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Swetha ParvathaneniDepartment of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Zhigang LiDepartment of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland, USA.
David B SacksDepartment of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: david.sacks2@nih.gov.
National Institutes of Health · US

Funding

IQGAP1 in tumorigenesisZIACL080017 · CLC · CLINICAL CENTER · PI SACKS, DAVID · 2012 to 2025
$0k
6 · The paper itself

Abstract

The mitogen-activated protein kinase (MAPK) cascade is a fundamental signaling pathway that regulates cell fate decisions in response to external stimuli. Several scaffold proteins bind directly to kinase components of this pathway and regulate their activation by growth factors. One of the best studied MAPK scaffolds is kinase suppressor of Ras1 (KSR1), which is induced by epidermal growth factor (EGF) to translocate to the plasma membrane where it activates extracellular signal-regulated kinase (ERK). While Ca

Indexed as

MAP Kinase Signaling SystemAnimalsCalmodulinMiceMitogen-Activated Protein KinasesProtein BindingProtein KinasesCalmodulinKSR-1 protein kinaseMitogen-Activated Protein KinasesProtein Kinasescalciumcalmodulinkinase suppressor of Ras1 (KSR1)mitogen-activated protein kinase (MAPK)protein–protein interactionsignaling

Identifiers

PMID33766558
PMCPMC8079274
OpenAlexW3137645651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.