Evidence map›Paper›PMID 33766478›Full record

ArticlePhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)2021

Intercomparison of Monte Carlo calculated dose enhancement ratios for gold nanoparticles irradiated by X-rays: Assessing the uncertainty and correct methodology for extended beams.

H Rabus, W B Li, C Villagrasa, J Schuemann, P A Hepperle, L de la Fuente Rosales, M Beuve, S Di Maria, A P Klapproth, C Y Li and 3 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

H RabusPhysikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany; European Radiation Dosimetry Group (EURADOS) e.V, Neuherberg, Germany.
W B LiInstitute of Radiation Medicine, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; European Radiation Dosimetry Group (EURADOS) e.V, Neuherberg, Germany.
C VillagrasaInstitut de Radioprotection et de Sûreté Nucléaire, Fontenay-Aux-Roses, France; European Radiation Dosimetry Group (EURADOS) e.V, Neuherberg, Germany.
J SchuemannMassachusetts General Hospital & Harvard Medical School, Department of Radiation Oncology, Boston, MA, USA; European Radiation Dosimetry Group (EURADOS) e.V, Neuherberg, Germany.
P A HepperlePhysikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany; Leibniz Universität Hannover, Hannover, Germany.
L de la Fuente RosalesPhysikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany.
M BeuveInstitut de Physique des 2 Infinis, Université Claude Bernard Lyon 1, Villeurbanne, France; European Radiation Dosimetry Group (EURADOS) e.V, Neuherberg, Germany.
S Di MariaCentro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Bobadela LRS, Portugal; European Radiation Dosimetry Group (EURADOS) e.V, Neuherberg, Germany.
A P KlapprothInstitute of Radiation Medicine, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; TranslaTUM, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
C Y LiDepartment of Engineering Physics, Tsinghua University, Beijing, China; Nuctech Company Limited, Beijing, China.
F PoignantInstitut de Physique des 2 Infinis, Université Claude Bernard Lyon 1, Villeurbanne, France; NASA Langley Research Center, Hampton, VA, USA.
B RudekPhysikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany; Massachusetts General Hospital & Harvard Medical School, Department of Radiation Oncology, Boston, MA, USA; Perlmutter Cancer Center, NYU Langone Health, New York City, NY, USA.
H NettelbeckPhysikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany; European Radiation Dosimetry Group (EURADOS) e.V, Neuherberg, Germany.

Funding

TOPAS - nBio, a Monte Carlo tool for radiation biology researchR01CA187003 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SCHUEMANN, JAN PATRICK OSCAR · 2015 to 2024
$4.8M
NCI NIH HHS R01 CA187003
6 · The paper itself

Abstract

Results of a Monte Carlo code intercomparison exercise for simulations of the dose enhancement from a gold nanoparticle (GNP) irradiated by X-rays have been recently reported. To highlight potential differences between codes, the dose enhancement ratios (DERs) were shown for the narrow-beam geometry used in the simulations, which leads to values significantly higher than unity over distances in the order of several tens of micrometers from the GNP surface. As it has come to our attention that the figures in our paper have given rise to misinterpretation as showing 'the' DERs of GNPs under diagnostic X-ray irradiation, this article presents estimates of the DERs that would have been obtained with realistic radiation field extensions and presence of secondary particle equilibrium (SPE). These DER values are much smaller than those for a narrow-beam irradiation shown in our paper, and significant dose enhancement is only found within a few hundred nanometers around the GNP. The approach used to obtain these estimates required the development of a methodology to identify and, where possible, correct results from simulations whose implementation deviated from the initial exercise definition. Based on this methodology, literature on Monte Carlo simulated DERs has been critically assessed.

Indexed as

GoldMetal NanoparticlesMonte Carlo MethodRadiographyRadiotherapy DosageUncertaintyX-RaysGoldDose enhancementGold nanoparticlesTargeted radiotherapyX-rays

Identifiers

PMID33766478
PMCPMC8187310

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.