Evidence map›Paper›PMID 33766429›Full record

ReviewBest practice & research. Clinical endocrinology & metabolism2021

Neural regulation of bone marrow adipose tissue.

Xiao Zhang, Mohamed G Hassan, Erica L Scheller

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Best practice & research. Clinical endocrinology & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. [Communications biology · 2024
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Life (Basel, Switzerland) · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Xiao ZhangDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.
Mohamed G HassanDepartment of Orthodontics, Faculty of Oral and Dental Medicine, South Valley University, Qena, Egypt; Department of Orthodontics, Faculty of Dentistry, October 6 University, Giza, Egypt.
Erica L SchellerDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA. Electronic address: scheller@wustl.edu.
Washington University in St. Louis · USOctober 6 University · EG

Funding

PERIPHERAL NERVE DISTRIBUTION AND FUNCTION WITHIN THE SKELETONU01DK116317 · NIDDK · WASHINGTON UNIVERSITY · PI SCHELLER, ERICA LYNN · 2017 to 2019
$1.1M
NIDDK NIH HHS U01 DK116317
6 · The paper itself

Abstract

Bone marrow adipose tissue (BMAT) is an important cellular component of the skeleton. Understanding how it is regulated by the nervous system is crucial to the study of bone and bone marrow related diseases. BMAT is innervated by sympathetic and sensory axons in bone and fluctuations in local nerve density and function may contribute to its distinct physiologic adaptations at various skeletal sites. BMAT is directly responsive to adrenergic signals. In addition, neural regulation of surrounding cells may modify BMAT-specific responses, providing many potential avenues for both direct and indirect neural regulation of BMAT metabolism. Lastly, BMAT and peripheral adipose tissues share the same autonomic pathways across the central neuraxis and regulation of BMAT may occur in diverse clinical settings of neurologic and metabolic disease. This review will highlight what is known and unknown about the neural regulation of BMAT and discuss opportunities for future research in the field.

Indexed as

Adipose TissueBone MarrowBone and BonesHumansadrenergic receptorbonebone marrow adipocytemesenchymal stem cellnervous systemneurotransmitter

Identifiers

PMID33766429
PMCPMC8440660
OpenAlexW3135950638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.