Observational studyRespiratory research2021
Frequency and functional translation of low muscle mass in overweight and obese patients with COPD.
Observational study in Respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Fat-Free Mass in Weight-Related Complications: A Rapid Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Targeting PLA2G7 ameliorates high-fat diet-induced pulmonary injury in obese mice, uncovering a key mechanistic link to obesity-associated COPD.Respiratory research · 2026Article
- Body mass index-related heterogeneity in diaphragm thickening fraction response to exercise training in stable chronic obstructive pulmonary disease.Frontiers in physiology · 2026Article
- Body compositions phenotypes of older adults with COPD.Frontiers in nutrition · 2024Article
- Body Composition, Physical Function and Exercise Capacity in Chronic Obstructive Pulmonary Disease.COPD · 2023Article
- Efficacy of interventions to alter measures of fat-free mass in people with COPD: a systematic review and meta-analysis.ERJ open research · 2023Review
- The role of diet and nutrition in the management of COPD.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Obesity Paradox in Lung Diseases: What Explains It?Obesity facts · 2023Review
- Association between appendicular lean mass and chronic obstructive pulmonary disease: epidemiological cross-sectional study and bidirectional Mendelian randomization analysis.Frontiers in nutrition · 2023Article
- Frequency and Functional Consequences of Low Appendicular Lean Mass and Sarcopenic Obesity in Patients with Asthma Referred for Pulmonary Rehabilitation.Obesity facts · 2023Article
- Abdominal obesity in COPD is associated with specific metabolic and functional phenotypes.Nutrition & metabolism · 2022Article
- Article
- The Paradox of Obesity in Patients with Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2022Article
- Association between body composition, sarcopenia and pulmonary function in chronic obstructive pulmonary disease.BMC pulmonary medicine · 2022Article
- Efficacy of community-based respiratory neuromuscular electrical stimulation on exercise capacity and quality of life in stable COPD: a randomized multicenter parallel-controlled trial protocol.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundCut offs for fat-free mass index (FFMI) and appendicular skeletal muscle mass index (ASMI) are available for diagnosing low muscle mass in patients with COPD. This study aimed to investigate: (1) the frequency of low muscle mass (FFMI and ASMI) applying different cut-offs and (2) the functional translation (clinical impact) of low muscle mass, in patients with COPD stratified into BMI categories.
methodsPatients with COPD were assessed regarding body composition, exercise capacity, quadriceps muscle strength, symptoms of anxiety and depression, dyspnea and quality of life upon referral to pulmonary rehabilitation. The proportion of patients with low muscle mass was compared among BMI categories. Clinical outcomes between patients with normal and low muscle mass within each BMI category were compared.
results469 patients with COPD were included for analyses. The frequency of patients classified as low FFMI varied significantly according to the choice of cut-off (32 to 54%; P < 0.05), whereas the frequency of patients with low ASMI was 62%. When applying age-gender-BMI-specific cut-offs, 254 patients (54%) were classified as low FFMI. The choice of the cut-off affected the frequency of patients with low muscle mass in all BMI categories. Overweight and obese patients with low muscle mass were more frequently males and presented worse pulmonary function, exercise capacity and muscle strength compared with overweight and obese patients with normal muscle mass.
conclusionsApproximately half of the overweight and obese patients with COPD have low muscle mass when applying age-gender-BMI-specific cut-offs. Low muscle mass is associated with worse functional outcomes in overweight and obese COPD patients.
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