Evidence map›Paper›PMID 33765893›Full record

ArticleThe Journal of international medical research2021

HIV infection and multiple sclerosis: a case with unexpected "no evidence of disease activity" status.

Fernando Labella, Fernando Acebrón, María Del Carmen Blanco-Valero, Alba Rodrígez-Martín, Ángela Monterde Ortega, Eduardo Agüera Morales

Open access · goldAbstract read
In one paragraph

Article in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Fernando LabellaUnidad de Gestión Clínica de Neurologia, Hospital Universitario Reina Sofía, Córdoba.ORCID https://orcid.org/0000-0002-9191-8831
Fernando AcebrónUnidad de Gestión Clínica de Neurologia, Hospital Universitario Reina Sofía, Córdoba.
María Del Carmen Blanco-ValeroUnidad de Gestión Clínica de Neurologia, Hospital Universitario Reina Sofía, Córdoba.
Alba Rodrígez-MartínUnidad de Gestión Clínica de Neurologia, Hospital Universitario Reina Sofía, Córdoba.
Ángela Monterde OrtegaUnidad de Gestión Clínica de Neurologia, Hospital Universitario Reina Sofía, Córdoba.
Eduardo Agüera MoralesUnidad de Gestión Clínica de Neurologia, Hospital Universitario Reina Sofía, Córdoba.
Hospital Universitario Reina Sofía · ESInstituto Maimónides de Investigación Biomédica de Córdoba · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system whose etiology remains unclear. It has been suggested that MS can be triggered by certain viruses; however, human immunodeficiency virus (HIV) infection is associated with reduced incidence of MS. We present the case of a young patient diagnosed with active relapsing-remitting MS whose clinical course substantially improved following HIV infection and treatment. The patient achieved no evidence of disease activity status without any disease-modifying drugs. Both HIV-induced immunosuppression and antiretroviral therapy may have attenuated the clinical course in this patient.

Indexed as

HIV InfectionsMultiple SclerosisMultiple Sclerosis, Relapsing-RemittingVirusesHumansEpstein–Barr virushighly active antiretroviral therapyhuman endogenous retrovirushuman immunodeficiency virusimmunosuppressionMultiple sclerosisno evidence of disease activity

Identifiers

PMID33765893
PMCPMC8166391
OpenAlexW3138644033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.