Evidence map›Paper›PMID 33765846›Full record

ArticleJournal of neurotrauma2021

Long-Term Psychiatric Outcomes in Adults with History of Pediatric Traumatic Brain Injury.

Hattan Arif, Emily A Troyer, Jane S Paulsen, Florin Vaida, Elisabeth A Wilde, Erin D Bigler, John R Hesselink, Tony T Yang, Olga Tymofiyeva, Owen Wade and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of neurotrauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. A Retrospective Study of Dental Trauma in Israel Military Personnel.Dental traumatology : official publication of International Association for Dental Traumatology · 2025
    Observational
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Novel Psychiatric Disorder 6 Months After Traumatic Brain Injury in Children and Adolescents.The Journal of neuropsychiatry and clinical neurosciences · 2023
    Article
  12. Traumatic Brain Injury in Children and Adolescents: Psychiatric Disorders 24 Years Later.The Journal of neuropsychiatry and clinical neurosciences · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Hattan ArifDepartments of Psychiatry, University of California, San Diego, San Diego, California, USA.
Emily A TroyerDepartments of Psychiatry, University of California, San Diego, San Diego, California, USA.
Jane S PaulsenDepartments of Neuroscience, University of Iowa, Iowa City, Iowa, USA.
Florin VaidaFamily Medicine and Public Health, University of California, San Diego, San Diego, California, USA.
Elisabeth A WildeDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Erin D BiglerDepartment of Psychology and Neuroscience, Brigham Young University, Provo, Utah, USA.
John R HesselinkRadiology, University of California, San Diego, San Diego, California, USA.
Tony T YangDepartment of Psychiatry, Division of Child and Adolescent Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Olga TymofiyevaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Owen WadePsychiatry, and University of Iowa, Iowa City, Iowa, USA.
Jeffrey E MaxDepartments of Psychiatry, University of California, San Diego, San Diego, California, USA.
University of Iowa · USUniversity of San Diego · USUniversity of California, San Francisco · USBrigham Young University · USUniversity of California San Diego · USUniversity of Utah · US

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
Magnetoencephalography and Neurobehavioral Outcome of Pediatric Traumatic Brain InjuryR01HD088438 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAX, JEFFREY EDWIN · 2017 to 2021
$3.1M
Statistical disease modeling and clinimetrics to prepare for preventive trials in huntington diseaseU01NS103475 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI PAULSEN, JANE S · 2020 to 2022
$1.7M
Statistical disease modeling and clinimetrics to prepare for preventive trials in huntington diseaseR01NS103475 · NINDS · UNIVERSITY OF IOWA · PI PAULSEN, JANE S, ZHANG, YING · 2017 to 2018
$1.2M
Neural mechanisms of meditation training in healthy and depressed adolescents: An MRI connectome studyR61AT009864 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TYMOFIYEVA, OLGA, YANG, TONY TUNG-I · 2019 to 2020
$822k
Preparing for preventive clinical trials in Huntington's diseaseR01NS105509 · NINDS · UNIVERSITY OF IOWA · PI PAULSEN, JANE S · 2018 to 2018
$658k
A Network Approach to Study Brain Plasticity in Children with Cognitive TrainingR21AT009173 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TYMOFIYEVA, OLGA · 2016 to 2017
$436k
NCATS NIH HHS UL1 TR001872NCCIH NIH HHS R21 AT009173NCCIH NIH HHS R61 AT009864NICHD NIH HHS R01 HD088438NIMH NIH HHS T32 MH018399NINDS NIH HHS R01 NS103475NINDS NIH HHS R01 NS105509NINDS NIH HHS U01 NS103475
6 · The paper itself

Abstract

The objective of the study was to compare psychiatric outcomes in adults with and without history of pediatric traumatic brain injury (TBI). Youth ages 6 to 14 years hospitalized for TBI from 1992 to 1994 were assessed at baseline and at 3, 6, 12, and 24 months post-injury. In the current study, psychiatric assessments were repeated at 24 years post-injury with the same cohort, now adults ages 29 to 39 years. A control group of healthy adults also was recruited for one-time cross-sectional assessments. Outcome measures included: 1) presence of a psychiatric disorder since the 24-month assessment not present before the TBI ("novel psychiatric disorder," NPD), or in the control group, the presence of a psychiatric disorder that developed after the mean age of injury of the TBI group plus 2 years; and 2) Time-to-Event for onset of an NPD during the same time periods. In the TBI group, NPDs were significantly more common, and presence of a current NPD was significantly predicted by presence of a pre-injury lifetime psychiatric disorder and by abnormal day-of-injury computed tomography (CT) scan. Compared with controls, the TBI group also had significantly shorter Time-to-Event for onset of any NPD. These findings demonstrate that long-term psychiatric outcomes in adults previously hospitalized for pediatric TBI are significantly worse when compared with adult controls without history of pediatric TBI, both in terms of prevalence and earlier onset of NPD. Further, in the TBI group, long-term NPD outcome is predicted independently by presence of pre-injury psychiatric disorder and abnormal day-of-injury CT scan.

Indexed as

AdolescentAdultAge FactorsBrain Injuries, TraumaticCase-Control StudiesChildCohort StudiesFemaleHospitalizationHumansMaleMental DisordersRisk FactorsTime FactorsTrauma Severity Indicesadolescent TBIchild TBIlong-term psychiatric outcomepsychiatric disordertraumatic brain injury

Identifiers

PMID33765846
PMCPMC8336207
OpenAlexW3137334140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.