Evidence map›Paper›PMID 33765676›Full record

ArticlePhysics in medicine and biology2021

Three-dimensional visualization and improved quantification with super-resolution ultrasound imaging - validation framework for analysis of microvascular morphology using a chicken embryo model.

İpek Özdemir, Kenneth Johnson, Shelby Mohr-Allen, Kara E Peak, Victor Varner, Kenneth Hoyt

Open access · greenAbstract read
In one paragraph

Article in Physics in medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Advancements in Three-Dimensional Super-Resolution Ultrasound Imaging: A Narrative Review.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  3. Super-Resolution Ultrasound Imaging for Monitoring the Therapeutic Efficacy of a Vascular Disrupting Agent in an Animal Model of Breast Cancer.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2024
    Article
  4. Article
  5. Article
  6. Ultrasound localization microscopy.Zeitschrift fur medizinische Physik · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. 3-D Super-Resolution Ultrasound Imaging for Monitoring Early Changes in Breast Cancer after Treatment with a Vascular-Disrupting Agent.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

İpek ÖzdemirDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, United States of America.ORCID 0000-0001-6807-9390
Kenneth JohnsonDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, United States of America.
Shelby Mohr-AllenDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, United States of America.
Kara E PeakDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, United States of America.
Victor VarnerDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, United States of America.
Kenneth HoytDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, United States of America.ORCID 0000-0003-2379-8273
The University of Texas at Dallas · US

Funding

Mechanical Control of Cell Proliferation and Branching Morphogenesis in the Embryonic LungR01HL145147 · NHLBI · UNIVERSITY OF TEXAS DALLAS · PI VARNER, VICTOR D. · 2019 to 2023
$1.9M
Multiparametric ultrasound imaging for early detection of nonalcoholic fatty liver diseaseR01DK126833 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI HOYT, KENNETH · 2021 to 2024
$1.6M
3D Super-Resolution Ultrasound Imaging for Cancer Detection and Treatment MonitoringR01EB025841 · NIBIB · UNIVERSITY OF TEXAS DALLAS · PI HOYT, KENNETH · 2019 to 2022
$1.3M
NHLBI NIH HHS R01 HL145147NIBIB NIH HHS R01 EB025841NIDDK NIH HHS R01 DK126833
6 · The paper itself

Abstract

The purpose of this study was to improve the morphological analysis of microvascular networks depicted in three-dimensional (3D) super-resolution ultrasound (SR-US) images. This was supported by qualitative and quantitative validation by comparison to matched brightfield microscopy and traditional B-mode ultrasound (US) images. Contrast-enhanced US (CEUS) images were collected using a preclinical US scanner (Vevo 3100, FUJIFILM VisualSonics Inc.) equipped with an MX250 linear array transducer. CEUS imaging was performed after administration of a microbubble (MB) contrast agent into the vitelline network of a developing chicken embryo. Volume data was collected by mechanically scanning the US transducer throughout a tissue volume-of-interest in 90

Indexed as

ChickensImaging, Three-DimensionalAnimalsChick EmbryoCross-Sectional StudiesMicrobubblesUltrasonographychicken embryomicrobubble contrast agentsmicrovascular morphologysuper-resolution ultrasound

Identifiers

PMID33765676
PMCPMC8463964
OpenAlexW3137106578

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.