ArticlePsychoneuroendocrinology2021
Identifying profiles of multisystem physiological activity across early childhood: Examining developmental shifts and associations with stress and internalizing problems.
Article in Psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adrenocortical and autonomic cross-system regulation in youth: A meta-analysis.Psychoneuroendocrinology · 2024Pooled it
- Hair Cortisol in Young Children with Autism and Their Parents: Associations with Child Mental Health, Eating Behavior and Weight Status.Journal of autism and developmental disorders · 2026Article
- Multisystem stress response biotypes: a precision psychiatry approach to identifying and treating multidimensional risk factors for anhedonia in adolescence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Associations between Autonomic and Endocrine Reactivity to Stress in Adolescence: Related to the Development of Anxiety?Healthcare (Basel, Switzerland) · 2023Article
- Association Between Dynamic Parasympathetic Reactivity to Frustration and Children's Social Success with Peers in Kindergarten.Research on child and adolescent psychopathology · 2021Article
- Developmental Consequences of Early Life Stress on Risk for Psychopathology: Longitudinal Associations with Children's Multisystem Physiological Regulation and Executive Functioning.Development and psychopathology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Physiological regulation is an important predictor of health across the lifespan. Regulation occurs across multiple collaborative systems, yet few empirical studies explore multisystem activity and how this collaborative regulation develops early in life. The current study used latent profile analysis to evaluate multisystem regulation in the autonomic nervous system and hypothalamic pituitary adrenal (HPA) axis in 150 racially/ethnically diverse, low-income children at 18- and 36-months. At both timepoints, profiles of generally moderate activity (Moderate Arousal) and heightened baseline activity (Anticipatory Arousal) emerged. A profile of typically adaptive patterns across all systems (Active Copers) emerged at 18-months and a profile of heightened HPA Axis activity (HPA-axis Responders) emerged at 36-months. Persistent membership in the Anticipatory Arousal profile across time was associated with exposure to greater maternal stress at 18-months and child internalizing problems at 36-months. These findings highlight early multisystem profile development and suggest associations with stress and later behavior problems.
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