ArticleImmunity2021
Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19.
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Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 261 papers.
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261citing papers in PubMed
48.3field-weighted citation impact, top 1% of its field
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Who cites it
261 citing papers in PubMed, 385 citations in OpenAlex.
- A gold nanoparticle/peptide vaccine designed to induce SARS-CoV-2-specific CD8 T cells: a double-blind, randomized, phase 1 study in Switzerland.BMC infectious diseases · 2025Trial
- Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19.Science advances · 2023Trial
- Randomized phase II clinical trial of ruxolitinib plus simvastatin in COVID19 clinical outcome and cytokine evolution.Frontiers in immunology · 2023Trial
- Monocytes in pneumonia: Functional plasticity and innate memory (Review).International journal of molecular medicine · 2026Review
- Spatiotemporal heterologous vaccination relies on type I interferons at priming to enhance mucosal immunity.EMBO molecular medicine · 2026Article
- Utility of Nasopharyngeal Aspirate Over Other Upper Airway Sampling Approaches for Cellular Immunology During Respiratory Viral Infection.The Journal of infectious diseases · 2026Article
- Migration of immune cells in tumors and inflammation: molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Alveolar macrophage-derived TGF-β promotes acute lung injury recovery by regulating inflammatory monocyte-derived macrophages.Journal of advanced research · 2026Article
- Alternative splicing of toll-like receptor pathway mRNAs in lung immune cells from patients with ARDS.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- CD8MedComm · 2026Review
- FcεRI+IgE+ monocytes are linked to atopy and allergic inflammation with distinct phenotypes and enhanced antiviral responses.bioRxiv : the preprint server for biology · 2026Article
- Scoring gene importance by interpreting single-cell foundation models.Nature biotechnology · 2026Article
- Article
- An intramuscular prime-intranasal boost strategy for mRNA-LNP vaccine induces mucosal immune response against SARS-CoV-2 in murine model.Journal of translational medicine · 2026Article
- Novel Approaches for Investigating Host Responses to HIV Infection in Ex Vivo Human Genital Tissues.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Activated immune cells present a lung interstitial-to-airway/alveolar cross-compartment sharing pattern in severe pneumonia.Clinical and translational medicine · 2026Article
- Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes.The Journal of experimental medicine · 2026Article
- Dual induction of tissue-resident T and B cell immunity for broad influenza protection with a nanofiber-VLP vaccine.Journal of nanobiotechnology · 2026Article
- Aryl hydrocarbon receptor activation alters emergency hematopoiesis during influenza A virus infection.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Alveolar Immune Profiling Identifies Distinct Subphenotypes of Acute Respiratory Failure.medRxiv : the preprint server for health sciences · 2026Article
201 more citing papers are in PubMed but not listed here.
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Authors and funding
24 authors at 3 institutions in 1 country.
Peter A SzaboDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Pranay DograDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Joshua I GrayDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Steven B WellsDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Thomas J ConnorsDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Stuart P WeisbergDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Izabela KrupskaDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Rei MatsumotoDepartment of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
Maya M L PoonDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Medical Scientist Training Program, Columbia University, New York, NY 10032, USA.
Emma IdzikowskiDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Sinead E MorrisDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Chloé PasinDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Andrew J YatesDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Amy KuDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Michael ChaitDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Julia Davis-PoradaMedical Scientist Training Program, Columbia University, New York, NY 10032, USA.
Xinzheng V GuoHuman Immune Monitoring Core, Columbia University Irving Medical Center, New York, NY 10032, USA.
Jing ZhouIsoPlexis Corporation, Branford, CT 06405, USA.
Matthew SteinleIsoPlexis Corporation, Branford, CT 06405, USA.
Sean MackayIsoPlexis Corporation, Branford, CT 06405, USA.
Anjali SaqiDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Matthew R BaldwinDepartment of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Peter A SimsDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Donna L FarberDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: df2396@cumc.columbia.edu.
Columbia University Irving Medical Center · USIsoPlexis (United States) · USColumbia University · US
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3MTranscriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3MViral Assays CoreU19AI128949 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Peter Alan Sims · 2017 to 2026
$26.4MModeling the development, structure and regulation of T cell memoryR01AI093870 · NIAID · UNIVERSITY OF GLASGOW · PI YATES, ANDREW · 2011 to 2025
$5.9MModeling the ecology of tissue-resident T cellsU01AI150680 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L., YATES, ANDREW · 2020 to 2024
$5.0MImmunobiology and alveolar physiology of the aging lungU01HL145547 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BHATTACHARYA, JAHAR, FARBER, DONNA L. · 2019 to 2022
$2.6MDevelopment of Localized T Cell Immunity in Pediatric Respiratory Tract InfectionK23AI141686 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CONNORS, THOMAS · 2019 to 2023
$973kTissue Resident Immune Cells in Human Pancreas.K08DK122130 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WEISBERG, STUART P · 2019 to 2023
$827kNCI NIH HHS P30 CA013696NHLBI NIH HHS U01 HL145547NIAID NIH HHS K23 AI141686NIAID NIH HHS P01 AI106697NIAID NIH HHS R01 AI093870NIAID NIH HHS U01 AI150680NIAID NIH HHS U19 AI128949NIDDK NIH HHS K08 DK122130
Abstract
Immune response dynamics in coronavirus disease 2019 (COVID-19) and their severe manifestations have largely been studied in circulation. Here, we examined the relationship between immune processes in the respiratory tract and circulation through longitudinal phenotypic, transcriptomic, and cytokine profiling of paired airway and blood samples from patients with severe COVID-19 relative to heathy controls. In COVID-19 airways, T cells exhibited activated, tissue-resident, and protective profiles; higher T cell frequencies correlated with survival and younger age. Myeloid cells in COVID-19 airways featured hyperinflammatory signatures, and higher frequencies of these cells correlated with mortality and older age. In COVID-19 blood, aberrant CD163
Indexed as
AdolescentAdultAgedAged, 80 and overAge FactorsCOVID-19CytokinesHumansInflammationLongitudinal StudiesLungMacrophagesMiddle AgedMonocytesMyeloid CellsSARS-CoV-2CytokinesARDSchemokinescoronavirus disease 2019COVID-19cytokineslung immunitymacrophagesmonocytessingle-cell RNA sequencingtissue resident memory T cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.