ArticleNeurobiology of aging2021
Specific and general relationships between cortical thickness and cognition in older adults: a longitudinal study.
Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Structural brain indicators of cognitive performance in middle and late adulthood: The Human Connectome Project in Aging/Aging Adult Brain Connectome cohort.Neurobiology of aging · 2026Article
- Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.Brain communications · 2026Article
- Effects of cortical thickness, volume, and memory performance on age differences in neural reinstatement of scene information.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Recollection-related fMRI effects in entorhinal cortex predict longitudinal memory change in healthy older adults.Neurobiology of aging · 2025Article
- Causal association of sarcopenia-related traits with brain cortical structure: a bidirectional Mendelian randomization study.Aging clinical and experimental research · 2025Article
- Free water-corrected fractional anisotropy of the fornix and parahippocampal cingulum predicts longitudinal memory change in cognitively healthy older adults.Neurobiology of aging · 2024Article
- Cortical thickness, gray matter volume, and cognitive performance: a crosssectional study of the moderating effects of age on their interrelationships.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Superficial white matter across development, young adulthood, and aging: volume, thickness, and relationship with cortical features.Brain structure & function · 2023Article
- Age- and sex-related differences in cortical morphology and their relationships with cognitive performance in healthy middle-aged and older adults.Quantitative imaging in medicine and surgery · 2023Article
- Effects of age on the neural correlates of encoding source and item information: An fMRI study.Neuropsychologia · 2022Article
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4 authors.
Funding
Abstract
Prior studies suggest that relationships between regional cortical thickness and domain-specific cognitive performance can be mediated by the relationship between global cortical thickness and domain-general cognition. Whether such findings extend to longitudinal cognitive change remains unclear. Here, we examined the relationships in healthy older adults between cognitive performance, longitudinal cognitive change over 3 years, and cortical thickness at baseline of the left and right inferior frontal gyrus (IFG) and left and right hemispheres. Both right IFG and right hemisphere thickness predicted baseline general cognition and domain-specific cognitive performance. Right IFG thickness was also predictive of longitudinal memory change. However, right IFG thickness was uncorrelated with cognitive performance and memory change after controlling for the mean thickness of other ipsilateral cortical regions. In addition, most identified associations between cortical thickness and specific cognitive domains were nonsignificant after controlling for the variance shared with other cognitive domains. Thus, relationships between right IFG thickness, cognitive performance, and memory change appear to be largely accounted for by more generic relationships between cortical thickness and cognition. This article is part of the Virtual Special Issue titled "COGNITIVE NEUROSCIENCE OF HEALTHY AND PATHOLOGICAL AGING". The full issue can be found on ScienceDirect athttps://www.sciencedirect.com/journal/neurobiology-of-aging/special-issue/105379XPWJP.
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