ArticleMethods in molecular biology (Clifton, N.J.)2021
A Mouse Model of Helicobacter pylori Infection.
Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Anti-Inflammatory and Antibacterial Properties of Curcuma longa Extract Against Helicobacter pylori.Molecular nutrition & food research · 2025Article
- Establishment of an intragastric surgical model using C57BL/6 mice to study the vaccine efficacy of OMV-based immunogens against Helicobacter pylori.Biology open · 2025Article
- A critical review onFrontiers in cellular and infection microbiology · 2025Review
- Developing a potent vaccine againstExpert reviews in molecular medicine · 2024Review
- Article
- Current research on the interaction between Helicobacter pylori and macrophages.Molecular biology reports · 2024Review
- Chitosan-LeoA-DNA Nanoparticles Promoted the Efficacy of Novel LeoA-DNA Vaccination on Mice Against Helicobacter pylori.Current microbiology · 2024Article
- Immune evasion by proteolytic shedding of natural killer group 2, member D ligands inFrontiers in immunology · 2024Article
- Effect ofFrontiers in pharmacology · 2024Article
- Cross-species single-cell transcriptomic analysis of animal gastric antrum reveals intense porcine mucosal immunity.Cell regeneration (London, England) · 2023Article
- Co-ingestion of glutamine and leucine synergistically promotes mTORC1 activation.Scientific reports · 2022Article
- Animal Models andJournal of clinical medicine · 2022Review
- Effect ofFrontiers in pharmacology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection with Helicobacter pylori (H. pylori) is of great distress because of its vital role in the pathogenesis of chronic gastritis, peptic ulcers, and in the multi-step carcinogenic process of gastric cancer. The increasing antibiotic resistance pattern of H. pylori worldwide has prompted the World Health Organization to put this organism in the priority pathogens list. To study the disease biology, evaluation of drugs, treatment outcome and to come up with probable vaccination strategies, competent animal models that reproduce the signature of human infection are essential. Initial reports about animal colonization with H. pylori have shown significant heterogeneity, to such an extent that Barry Marshall, Nobel laureate for the discovery of H. pylori , infected himself with the bacterium to show its involvement in acute gastric illness. A paradigm-shift discovery of the H. pylori mouse-adapted strain SS1 has opened the avenues of research regarding the organism and its pathogenicity. Although the mouse model of H. pylori infection is being utilized all over the world, there are certain issues that need awareness and specific information to achieve successful, consistent colonization with symptoms resembling human. This chapter details an established and reliable protocol for the development of a competent mouse model for H. pylori infection leading to various gastro-intestinal diseases.
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