ArticlePloS one2021
Model choice for estimating the association between exposure to chemical mixtures and health outcomes: A simulation study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- When are novel methods for analyzing complex chemical mixtures in epidemiology beneficial?Environmental epidemiology (Philadelphia, Pa.) · 2026Review
- The upside and challenge of getting it wrong.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Application of Toxicologically Informed Relative Potency Factors to Examine Associations between Water Disinfection Byproducts and Birth Defects.Environmental science & technology · 2025Article
- Statistical Methods for Chemical Mixtures: A Roadmap for Practitioners Using Simulation Studies and a Sample Data Analysis in the PROTECT Cohort.Environmental health perspectives · 2025Article
- Endocrine-Disrupting Chemicals and Persistent Nausea among Pregnant Women Enrolled in the Illinois Kids Development Study (I-KIDS).Environmental health perspectives · 2025Article
- The association between urban land use and depressive symptoms in young adulthood: a FinnTwin12 cohort study.Journal of exposure science & environmental epidemiology · 2024Article
- Associations of urinary non-persistent endocrine disrupting chemical biomarkers with early-to-mid pregnancy plasma sex-steroid and thyroid hormones.Environment international · 2024Article
- Methodological Challenges in Spatial and Contextual Exposome-Health Studies.Critical reviews in environmental science and technology · 2023Article
- Using non-parametric Bayes shrinkage to assess relationships between multiple environmental and social stressors and neonatal size and body composition in the Healthy Start cohort.Environmental health : a global access science source · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Challenges arise in researching health effects associated with chemical mixtures. Several methods have recently been proposed for estimating the association between health outcomes and exposure to chemical mixtures, but a formal simulation study comparing broad-ranging methods is lacking. We select five recently developed methods and evaluate their performance in estimating the exposure-response function, identifying active mixture components, and identifying interactions in a simulation study. Bayesian kernel machine regression (BKMR) and nonparametric Bayes shrinkage (NPB) were top-performing methods in our simulation study. BKMR and NPB outperformed other contemporary methods and traditional linear models in estimating the exposure-response function and identifying active mixture components. BKMR and NPB produced similar results in a data analysis of the effects of multipollutant exposure on lung function in children with asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.