Evidence map›Paper›PMID 33765045›Full record

ArticlePloS one2021

Clinical and ultrasonographic features of choroidal metastases based on primary cancer site: Long-term experience in a single center.

Maria Antonietta Blasi, Martina Maceroni, Carmela Grazia Caputo, Maria Grazia Sammarco, Andrea Scupola, Jacopo Lenkowicz, Giovanni Schinzari, Ernesto Rossi, Monica Maria Pagliara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. Article
  8. Point-of-care Ultrasound Diagnosed Intraocular Breast Metastasis.Clinical practice and cases in emergency medicine · 2024
    Article
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maria Antonietta BlasiUniversità Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0001-6812-1210
Martina MaceroniUniversità Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0002-3754-7486
Carmela Grazia CaputoUOC Oncologia Oculare, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy.
Maria Grazia SammarcoUOC Oncologia Oculare, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy.
Andrea ScupolaUOC Oncologia Oculare, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy.
Jacopo LenkowiczFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Giovanni SchinzariUniversità Cattolica del Sacro Cuore, Rome, Italy.
Ernesto RossiOncologia Medica, Fondazione Policlinico Universitario, A. Gemelli IRCCS, Rome, Italy.
Monica Maria PagliaraUOC Oncologia Oculare, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy.
Agostino Gemelli University Polyclinic · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and purposeChoroidal metastases (CM) are the most common intraocular malignancies. With longer survival rates for cancer patients, CM will be increasingly encountered. We evaluated clinical and ultrasonographic (US) characteristics of CM in order to identify diagnostic biomarkers that correlate with the primary tumor site.

methodsThe medical records of all patients with CM evaluated at the Ocular Oncology Unit between February 2010 and March 2020 were analyzed.

results82 eyes of 70 patients were included. The primary cancer site was lung in 26 patients (37%), breast in 23 (33%), kidney in 9 (13%), gastrointestinal in 5 (7%), thyroid in 5 (7%), parathyroids and prostate respectively in 2 (3%). Fifty-five patients (78%) had other systemic metastases at the time of ocular diagnosis. Ten (14%) patients had no history of primary cancer. Bilateral CM were found in 20 patients (29%); fifty-six eyes (68%) had a single CM. The epicenter of CM was predominantly macula (43 eyes, 52%). The mean thickness was 4,1 mm (range 1,8-12,3). US structure was inhomogeneous in 67 eyes (82%). Reflectivity was mainly medium (39%) and medium-low (39%). In particular, CM from lung cancer showed lower reflectivity than those from the breast (p = 0,02). CM deriving from lung cancer were typically dome-shaped, whereas CM originating from breast were characteristically plateau shaped (p = 0,02). Seventy-four (91%) eyes presented fluid on optical coherence tomography.

conclusionWe significatively found that CM from lung cancer generally appear dome-shaped with medium-low internal reflectivity, whereas those from breast cancer typically present a plateau appearance and higher internal reflectivity. Though it is hard to identify the site of the primary tumor relying exclusively on clinical and US aspects, morphology and internal reflectivity can be considered as diagnostic biomarkers. Thus, the origin of the primary tumor can be suspected by integrating a constellation of findings.

Indexed as

UltrasonographyAdultAgedAged, 80 and overBreast NeoplasmsChoroidChoroid NeoplasmsFemaleHumansKidney NeoplasmsLung NeoplasmsMacula LuteaMaleMiddle AgedRetrospective StudiesTomography, Optical Coherence

Identifiers

PMID33765045
PMCPMC7993812
OpenAlexW3139348474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.