ArticlePloS one2021
Shifts in the epidemic season of human respiratory syncytial virus associated with inbound overseas travelers and meteorological conditions in Japan, 2014-2017: An ecological study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 20 citations in OpenAlex.
- Spatial heterogeneity in the burden of respiratory syncytial virus infection attributable to low and high ambient temperature in Japan: a nationwide time-stratified case-crossover analysis.Respiratory research · 2026Article
- Nationwide epidemiology of invasive meningococcal disease in Japan, 2017-2025: implications of post-COVID-19 mobility.Tropical medicine and health · 2026Article
- Interplay between climate and childhood mixing can explain a sudden shift in RSV seasonality in Japan.Nature communications · 2025Article
- Epidemiology of moderate-to-severe respiratory syncytial virus infections in children in subtropical Okinawa, Japan: a 4-year retrospective study.Tropical medicine and health · 2025Article
- Global outbreaks of respiratory syncytial virus infections from 1960 to 2025: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Associations Between Environmental Conditions and Infection With Respiratory Syncytial Virus in Japan: A Spatiotemporal Analysis.Open forum infectious diseases · 2025Article
- Detailed analysis of low temperature inactivation of respiratory syncytial virus.Scientific reports · 2024Article
- Nonlinear and Multidelayed Effects of Meteorological Drivers on Human Respiratory Syncytial Virus Infection in Japan.Viruses · 2023Article
- Impact of meteorological and demographic factors on the influenza epidemic in Japan: a large observational database study.Scientific reports · 2023Observational
- Article
- Respiratory virus circulation in children after relaxation of COVID-19 restrictions in fall 2021-A nationwide register study in Finland.Journal of medical virology · 2022Article
- The Effect of International Travel Arrivals on the New HIV Infections in 15-49 Years Aged Group Among 109 Countries or Territories From 2000 to 2018.Frontiers in public health · 2022Article
- Decreased human respiratory syncytial virus activity during the COVID-19 pandemic in Japan: an ecological time-series analysis.BMC infectious diseases · 2021Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few studies have examined the effects of inbound overseas travelers and meteorological conditions on the shift in human respiratory syncytial virus (HRSV) season in Japan. This study aims to test whether the number of inbound overseas travelers and meteorological conditions are associated with the onset week of HRSV epidemic season. The estimation of onset week for 46 prefectures (except for Okinawa prefecture) in Japan for 4-year period (2014-2017) was obtained from previous papers based on the national surveillance data. We obtained data on the yearly number of inbound overseas travelers and meteorological (yearly mean temperature and relative humidity) conditions from Japan National Tourism Organization (JNTO) and Japan Meteorological Agency (JMA), respectively. Multi-level mixed-effects linear regression analysis showed that every 1 person (per 100,000 population) increase in number of overall inbound overseas travelers led to an earlier onset week of HRSV epidemic season in the year by 0.02 week (coefficient -0.02; P<0.01). Higher mean temperature and higher relative humidity were also found to contribute to an earlier onset week by 0.30 week (coefficient -0.30; P<0.05) and 0.18 week (coefficient -0.18; P<0.01), respectively. Additionally, models that included the number of travelers from individual countries (Taiwan, South Korea, and China) except Australia showed that both the number of travelers from each country and meteorological conditions contributed to an earlier onset week. Our analysis showed the earlier onset week of HRSV epidemic season in Japan is associated with increased number of inbound overseas travelers, higher mean temperature, and relative humidity. The impact of international travelers on seasonality of HRSV can be further extended to investigations on the changes of various respiratory infectious diseases especially after the coronavirus disease 2019 (COVID-19) pandemic.
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