Evidence map›Paper›PMID 33765001›Full record

ArticlePloS one2021

"It really proves to us that we are still valuable": Qualitative research to inform a safer conception intervention for men living with HIV in South Africa.

Lynn T Matthews, Letitia Greener, Hazar Khidir, Christina Psaros, Abigail Harrison, F Nzwakie Mosery, Mxolisi Mathenjwa, Kasey O'Neil, Cecilia Milford, Steven A Safren and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Lynn T MatthewsUniversity of Alabama at Birmingham, Birmingham, AL, United States of America.ORCID 0000-0001-6167-6328
Letitia GreenerDepartment of Obstetrics and Gynaecology, MRU (MatCH), University of the Witwatersrand, Faculty of Health Sciences, Durban, South Africa.
Hazar KhidirHarvard Medical School, Massachusetts General Hospital, Brigham and Women's Hospital, Combined Residency Program in Emergency Medicine, Boston, MA, United States of America.
Christina PsarosDepartment of Psychiatry, Massachusetts General Hospital, Behavioral Medicine, Boston, MA, United States of America.
Abigail HarrisonDepartment of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, United States of America.
F Nzwakie MoseryDepartment of Obstetrics and Gynaecology, MRU (MatCH), University of the Witwatersrand, Faculty of Health Sciences, Durban, South Africa.
Mxolisi MathenjwaDepartment of Obstetrics and Gynaecology, MRU (MatCH), University of the Witwatersrand, Faculty of Health Sciences, Durban, South Africa.
Kasey O'NeilCenter for Global Health and Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States of America.
Cecilia MilfordDepartment of Obstetrics and Gynaecology, MRU (MatCH), University of the Witwatersrand, Faculty of Health Sciences, Durban, South Africa.
Steven A SafrenDepartment of Psychology, University of Miami, Coral Gables, FL, United States of America.
David R BangsbergOregon Health & Science University-Portland State University School of Public Health, Portland, OR, United States of America.
Jennifer A SmitDepartment of Obstetrics and Gynaecology, MRU (MatCH), University of the Witwatersrand, Faculty of Health Sciences, Durban, South Africa.
University of the Witwatersrand · ZAMassachusetts General Hospital · USBrigham and Women's Hospital · USBrown University · USPortland State University · USUniversity of Alabama at Birmingham · USUniversity of Miami · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Addressing psychosocial comorbidities in HIV treatment and preventionK24MH094214 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI SAFREN, STEVEN A · 2011 to 2015
$858k
Periconception HIV risk reduction for HIV-discordant couples in UgandaK23MH095655 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MATTHEWS, LYNN T · 2011 to 2015
$854k
Perinatal Depression, Stigma, Social Capital Utilization and PMTCT AdherenceK23MH096651 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI PSAROS, CHRISTINA · 2012 to 2016
$843k
Mentoring Patient Oriented Adherence Research in UgandaK24MH087227 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BANGSBERG, DAVID ROY · 2009 to 2013
$776k
ART-based safer conception for HIV+ South African men who want to have childrenR34MH100948 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MATTHEWS, LYNN T · 2014 to 2016
$521k
NIAID NIH HHS P30 AI060354NIMH NIH HHS K23 MH095655NIMH NIH HHS K23 MH096651NIMH NIH HHS K24 MH087227NIMH NIH HHS K24 MH094214NIMH NIH HHS R34 MH100948
6 · The paper itself

Abstract

objectiveMany men living with HIV want to have children. Opportunities to reduce periconception HIV transmission include antiretroviral therapy as prevention, pre-exposure prophylaxis, limiting condomless sex to peak fertility, and sperm processing. Whether men have knowledge of or want to adopt these strategies remains unknown.

methodsWe conducted focus group discussions (FGDs) with men accessing HIV care in South Africa in 2014 to inform a safer conception intervention for men. Eligible men were 25-45 years old, living with HIV, not yet accessing treatment, and wanting to have a child with an HIV-negative or unknown serostatus female partner (referred to as the "desired pregnancy partner"). FGDs explored motivations for having a healthy baby, feasibility of a clinic-based safer conception intervention, and acceptability of safer conception strategies. Data were analyzed using thematic analysis.

resultsTwelve participants from three FGDs had a median age of 37 (range 23-45) years, reported a median of 2 (range 1-4) sexual partners, and 1 (range 1-3) desired pregnancy partner(s). A third (N = 4) had disclosed HIV-serostatus to the pregnancy partner. Emergent themes included opportunities for and challenges to engaging men in safer conception services. Opportunities included enthusiasm for a clinic-based safer conception intervention and acceptance of some safer conception strategies. Challenges included poor understanding of safer conception strategies, unfamiliarity with risk reduction [versus "safe" (condoms) and "unsafe" (condomless) sex], mixed acceptability of safer conception strategies, and concerns about disclosing HIV-serostatus to a partner.

conclusionsMen living with HIV expressed interest in safer conception and willingness to attend clinic programs. Imprecise prevention counseling messages make it difficult for men to conceptualize risk reduction. Effective safer conception programs should embrace clear language, e.g. undetectable = untransmittable (U = U), and support multiple approaches to serostatus disclosure to pregnancy partners.

Indexed as

AdultAnti-Retroviral AgentsFemaleFertilizationFocus GroupsHIV InfectionsHumansInterviews as TopicMaleMiddle AgedQualitative ResearchSafe SexSexual PartnersSouth AfricaYoung AdultAnti-Retroviral Agents

Identifiers

PMID33765001
PMCPMC7993862
OpenAlexW3137221013

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.