Evidence map›Paper›PMID 33764653›Full record

ArticleHuman brain mapping2021

Selective morphological and volumetric alterations in the hippocampus of children exposed in utero to gestational diabetes mellitus.

Kirsten M Lynch, Jasmin M Alves, Ting Chow, Kristi A Clark, Shan Luo, Arthur W Toga, Anny H Xiang, Kathleen A Page

Open access · goldAbstract read
In one paragraph

Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Structural and Functional Brain Changes in Children and Adolescents With Obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  8. Review
  9. Linking pregnancy- and birth-related risk factors to a multivariate fusion of child cortical structure.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Gestational Diabetes: An Update 60 Years After O'Sullivan and Mahan.The Journal of clinical endocrinology and metabolism · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kirsten M LynchMark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-3976-5783
Jasmin M AlvesDivision of Endocrinology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-0837-9858
Ting ChowDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Kristi A ClarkDepartment of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Shan LuoDivision of Endocrinology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Arthur W TogaMark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Anny H XiangDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Kathleen A PageDivision of Endocrinology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-9083-6615
University of Southern California · USKaiser Permanente · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2022
$14.1M
TrainingU54EB020406 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2014 to 2018
$12.5M
Neuroendocrine Systems involved in Early-life Programming for Obesity and DiabetesR01DK116858 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PAGE, KATHLEEN ALANNA, XIANG, ANNY H · 2019 to 2023
$3.5M
Genetic Influences on Human Neuroanatomical ShapesR01MH094343 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2016
$2.4M
Neural Mechanisms of Overeating Among Children Exposed to Gestational Diabetes Mellitus In UteroK01DK115638 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LUO, SHAN · 2018 to 2021
$758k
Neural mechanisms for obestity risk in children exposed to diabetes in uteroR03DK103083 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PAGE, KATHLEEN ALANNA · 2014 to 2015
$165k
The effects of in utero exposure to gestational diabetes on hippocampal structure and functionF31MH115640 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALVES, JASMIN · 2018 to 2019
$90k
NCATS NIH HHS UL1 TR001855NIBIB NIH HHS P41 EB015922NIBIB NIH HHS P41EB015922NIBIB NIH HHS U54 EB020406NIBIB NIH HHS U54EB020406NIDDK NIH HHS K01 DK115638NIDDK NIH HHS R01 DK116858NIDDK NIH HHS R01DK116858NIDDK NIH HHS R03 DK103083NIH HHS K01DK115638NIH HHS UL1TR001855NIMH NIH HHS F31MH115640NIMH NIH HHS R01MH094343
6 · The paper itself

Abstract

Prior epidemiological studies have found that in utero exposure to gestational diabetes mellitus (GDM) is associated with increased risk for neurodevelopmental disorders. However, brain alterations associated with GDM are not known. The hippocampus is pivotal for cognition and emotional regulation. Therefore, we assessed relationships between in utero exposure to GDM and hippocampal morphology and subfield structure during childhood. One hundred seventeen children aged 7-11 years (57% girls, 57% exposed to GDM), born at Kaiser Permanente Southern California, participated in the BrainChild Study. Maternal GDM status was determined from electronic medical records. Children underwent brain magnetic resonance imaging. Freesurfer 6.0 was used to measure hippocampal and individual hippocampal subfield gray matter volume (mm

Indexed as

Diabetes, GestationalCA1 Region, HippocampalChildFemaleHippocampusHumansMagnetic Resonance ImagingMalePregnancyPrenatal Exposure Delayed EffectsSex Factorsdevelopmental programminggestational diabeteshippocampal shape analysishippocampal subfield analysis

Identifiers

PMID33764653
PMCPMC8090774
OpenAlexW3139091577

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.