ArticleThe EMBO journal2021
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.
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Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
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132citing papers in PubMed
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Who cites it
132 citing papers in PubMed, 201 citations in OpenAlex.
- Trial
- Cytotoxic CD4Nature aging · 2026Article
- Single-Cell Mapping Identifies Aging-Associated Neutrophil Remodeling Across Multiple Organs.Aging cell · 2026Article
- Telomere-associated non-malignant pulmonary diseases: Pathogenic mechanisms and therapeutic strategies.Acta pharmaceutica Sinica. B · 2026Review
- Article
- The ageing immune system as a driver of systemic ageing.Nature reviews. Immunology · 2026Review
- Insights into the therapeutic strategies for aging and aging-associated diseases.Signal transduction and targeted therapy · 2026Review
- High altitude-mediated immune remodeling accelerates aging.Science advances · 2026Article
- The Role of Neutrophil, Monocyte and Macrophage Calprotectin and S100A12 in the Fibrotic Process.Biomolecules · 2026Review
- Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes.The Journal of clinical investigation · 2026Article
- Psoriasis-like disease prevents squamous skin tumor development by neutrophil-driven inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Host Aging Induces a Senescent-Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus pneumoniae.Aging cell · 2026Article
- ROS Activated NETosis of Bone Marrow CD55Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Fisetin-Mediated Topical Modulation of Senescent Cells in Skin Improves Wound Healing Dynamics in Diabetic Mice.Advances in wound care · 2026Article
- Identification and Validation of Liver Transplantation-Induced Acute Lung Injury Biomarkers Using a Bioinformatics and Experimental Approach.Annals of transplantation · 2026Article
- Tissue Immunometabolism in Autoimmunity.European journal of immunology · 2026Review
- Characteristic Changes in the Immune Landscape of Aging Liver: From Basic Mechanism to Clinical Transformation.Journal of immunology research · 2026Review
- Persistent pneumococcal colonisation in antiretroviral-treated HIV infection is associated with nasal inflammation.Nature communications · 2025Article
- Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice.Cell metabolism · 2025Article
- Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues.The EMBO journal · 2025Article
72 more citing papers are in PubMed but not listed here.
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Authors and funding
37 authors at 11 institutions in 5 countries.
Anthony LagnadoDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Jack LeslieNewcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Marie-Helene Ruchaud-SparaganoTranslational Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Stella VictorelliDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Petra HirsovaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Mikolaj OgrodnikDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Amy L CollinsNewcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Maria Grazia VizioliDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Leena HabiballaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Gabriele SaretzkiAgeing Research Laboratories, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Shane A EvansDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Hanna SalmonowiczDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Adam HrubyDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Daniel GehNewcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Kevin D PavelkoDepartment of Immunology and Immune Monitoring Core, Mayo Clinic, Rochester, MN, USA.
David DolanComputational Biology Unit, University of Bergen, Bergen, Norway.
Helen L ReevesNewcastle University Translational and Clinical Research Institute, Liver Unit, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.
Sushma GrellscheidComputational Biology Unit, University of Bergen, Bergen, Norway.
Colin H WilsonDepartment of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Sanjay PandanaboyanaDepartment of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Madison DoolittleRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Thomas von ZglinickiAgeing Research Laboratories, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Fiona OakleyNewcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Suchira GallageDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Caroline L WilsonNewcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Jodie BirchAgeing Research Laboratories, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0003-1727-1125
Bernadette CarrollSchool of Biochemistry, University of Bristol, Bristol, UK.
James ChapmanAgeing Research Laboratories, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Mathias HeikenwalderDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nicola NerettiDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Sundeep KhoslaRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Claudio Akio MasudaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Tamar TchkoniaRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-4623-7145
James L KirklandRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Diana JurkDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Derek A MannNewcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0003-0950-243X
João F PassosDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-8765-1890
Mayo Clinic in Florida · USNewcastle University · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GBBrown University · USGerman Cancer Research Center · DEMayo Clinic in Arizona · USDurham University · GBNIHR Newcastle Biomedical Research Centre · GBUniversidade Federal do Rio de Janeiro · BRUniversity of Bergen · NOUniversity of Bristol · GB
Funding
Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4MTargeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla · 2019 to 2026
$28.7MPILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI GREGORY J. GORES · 2009 to 2026
$22.2MEffect of Aging on Preadipocyte DifferentiationR37AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 2016 to 2025
$6.6MThe Role of Somatic Transposition in Age-associated Genomic InstabilityR01AG050582 · NIA · BROWN UNIVERSITY · PI NERETTI, NICOLA, SEDIVY, JOHN M · 2017 to 2022
$2.2MThe role of sub-lethal mitochondrial apoptotic stress in cellular senescenceR01AG068048 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2020 to 2024
$2.2MDoes obesity exacerbate age-related cognitive decline via senescence?R01AG068182 · NIA · MAYO CLINIC ROCHESTER · PI JURK, DIANA · 2020 to 2024
$2.0MPostdoctoral Training Program for Research on AgingT32AG049672 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2016 to 2022
$1.3MDevelopment of machine learning software to quantitatively map telomere induced senescence in tissue sections during agingUG3CA268103 · NCI · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2021 to 2022
$1.1MBiotechnology and Biological Sciences Research Council BB/K017314/1Biotechnology and Biological Sciences Research Council BB/L502066/1Biotechnology and Biological Sciences Research Council BB/S006710/1Cancer Research UK 23390Cancer Research UK 26813Cancer Research UK C18342/A23390Medical Research Council G0900535Medical Research Council MR/K001949/1Medical Research Council MR/K0019494/1Medical Research Council MR/R023026/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/K000748/1NCATS NIH HHS UL1 TR002377NCI NIH HHS UG3 CA268103NIA NIH HHS P01 AG062413NIA NIH HHS R01 AG050582NIA NIH HHS R01 AG068048NIA NIH HHS R01 AG068182NIA NIH HHS R37 AG013925NIA NIH HHS T32 AG049672NIDDK NIH HHS P30 DK084567
Abstract
Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro-inflammatory phenotype, thought to contribute to aging and age-related diseases. Neutrophils have essential roles in inflammatory responses; however, in certain contexts their abundance is associated with a number of age-related diseases, including liver disease. The relationship between neutrophils and cellular senescence is not well understood. Here, we show that telomeres in non-immune cells are highly susceptible to oxidative damage caused by neighboring neutrophils. Neutrophils cause telomere dysfunction both in vitro and ex vivo in a ROS-dependent manner. In a mouse model of acute liver injury, depletion of neutrophils reduces telomere dysfunction and senescence. Finally, we show that senescent cells mediate the recruitment of neutrophils to the aged liver and propose that this may be a mechanism by which senescence spreads to surrounding cells. Our results suggest that interventions that counteract neutrophil-induced senescence may be beneficial during aging and age-related disease.
Indexed as
Telomere ShorteningAcute Lung InjuryAnimalsCarbon TetrachlorideCell LineCellular SenescenceCoculture TechniquesDisease Models, AnimalFemaleFibroblastsHumansMaleMiceNeutrophilsOxidative StressParacrine CommunicationCarbon TetrachlorideReactive Oxygen Speciesagingneutrophilssenescencetelomeres
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.