SynthesisJournal of rehabilitation medicine2021
Safety and efficacy of mesotherapy in musculoskeletal disorders: A systematic review of randomized controlled trials with meta-analysis.
Synthesis in Journal of rehabilitation medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06610032 (The Comparison o the Efficacy of Mesotherapy and Intra-articular Steroid Injection in Patients With Chronic Shoulder Pain), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Comparison o the Efficacy of Mesotherapy and Intra-articular Steroid Injection in Patients With Chronic Shoulder Pain
Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Comparison of Mesotherapy and Transcutaneous Electrical Nerve Stimulation (TENS) in the Management of Chronic Non-Specific Low Back Pain: A Randomized Clinical Trial.La Tunisie medicale · 2025Trial
- Efficacy of Mesotherapy for Pain, Function and Quality of Life in Patients with Mild and Moderate Knee Osteoarthritis: A Randomized Controlled Trial.Journal of musculoskeletal & neuronal interactions · 2023Trial
- Efficacy of mesotherapy in patients with acute and subacute neck pain: A randomized controlled trial.Turkish journal of physical medicine and rehabilitation · 2026Article
- Comparing the Effect of Subcutaneous and Intradermal Mesotherapy on Pain and Function in Knee Osteoarthritis: A Randomized Clinical Trial : Short title: Subcutaneous vs. Intradermal Mesotherapy in Knee Osteoarthritis.Galen medical journal · 2026Article
- International Consensus Guidelines on the Safe and Evidence-Based Practice of Mesotherapy: A Multidisciplinary Statement.Journal of clinical medicine · 2025Article
- Shoulder Tendinopathy Induced by Statins: A Case Report and Systematic Review.Journal of personalized medicine · 2025Article
- The Effect of Intradermal Injection with Two Different Injection Techniques on Pain and Functional Status in Patients with Chronic Nonspecific Neck Pain.Medeniyet medical journal · 2024Article
- The Role of Rehabilitation after Spinal Mesotherapy in a Three-Stage Treatment Concept.Journal of clinical medicine · 2024Review
- Comparison of the Efficacy of Two Different Local Anesthesia Techniques for Mesotherapy in Temporal Region Alopecia.Cureus · 2024Article
- Efficacy and Safety of Spinal Collagen Mesotherapy in Patients with Chronic Low Back Pain in a Three-Month Follow-Up-Retrospective Study.Journal of clinical medicine · 2024Article
- Effects of Intradermal Therapy (Mesotherapy) on Bilateral Cervicobrachial Pain.Journal of personalized medicine · 2024Article
- Neck Pain in Fibromyalgia: Treatment with Exercise and Mesotherapy.Biomedicines · 2023Article
- A Call to Action by the Italian Mesotherapy Society on Scientific Research.Drug design, development and therapy · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo conduct a systematic review of randomized controlled trials about the safety (number and severity of adverse events) and efficacy (pain reduction and functional improvement) of mesotherapy in musculoskeletal disorders, and to compare them with other therapeutic options, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement.
methodsA search of PubMed, Cochrane Library and Scopus database resulted in an initial total of 16,253 records. A total of 931 articles were included in the study. A final total of 7 articles, published from 1 Jan 1999 until 30 Apr 2020 were selected. Two independent reviewers selected potentially relevant studies based on the inclusion criteria for full-text reading. They evaluated the methodological quality of each study and included only studies of high methodological quality, according to the Physiotherapy Evidence Database scale.
resultsSeven studies were included in the meta-analysis, and visual analogue scale scores before and after mesotherapy were considered. A statistically significant reduction in visual analogue scale score in the mesotherapy group was reported in comparison with the control group in all except 1 of the trials. Mesotherapy was found to be a safe procedure with mild and temporary side-effects, such as nausea, fatigue, numbness, sweating, headache, ecchymosis, bleeding, pain and local reaction at the injection site.
conclusionMesotherapy proved to be more effective than systemic therapy in the treatment of local pain and functional limitations caused by a variety of musculoskeletal conditions. However, because of the heterogeneity of the analysed studies in terms of injected drugs, administration technique, associated treatments, frequency and total number of sessions, more randomized controlled trials are needed, comparing a standardized mesotherapy protocol with a systemic treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.