Evidence map›Paper›PMID 33764197›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2022

Impact of COVID-19 on multiple sclerosis care and management: Results from the European Committee for Treatment and Research in Multiple Sclerosis survey.

Emilio Portaccio, Mattia Fonderico, Bernhard Hemmer, Tobias Derfuss, Bruno Stankoff, Krzysztof Selmaj, Mar Tintorè, Maria Pia Amato

Open access · hybridAbstract read
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Article
  3. COVID-19 and Radiological Progression of Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. SARS-CoV-2 Vaccines and Multiple Sclerosis: An Update.Neurology(R) neuroimmunology & neuroinflammation · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Adherence to Therapy in Patients with Multiple Sclerosis-Review.International journal of environmental research and public health · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 5 countries.

Emilio PortaccioUniversity Hospital Careggi, Florence, Italy.
Mattia FondericoDepartment of Neurofarba, University of Florence, Florence, Italy.ORCID 0000-0002-1716-5579
Bernhard HemmerNeurology Department, Klinikum rechts der Isar TU München, Münich, Germany/Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.ORCID 0000-0001-5985-6784
Tobias DerfussDepartments of Neurology and Biomedicine, University Hospital of Basel, Basel, Switzerland.ORCID 0000-0001-8431-8769
Bruno StankoffDepartment of Neurology, ICM, Hôpital Pitié Salpêtrière, Paris, France.
Krzysztof SelmajDepartment of Neurology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Mar TintorèDepartment of the Neurology/Neuroimmunology and Research Institute Barcelona, Multiple Sclerosis Centre of Catalonia (Cemcat), Barcelona, Spain.ORCID 0000-0001-9999-5359
Maria Pia AmatoDepartment of Neurofarba, University of Florence, Florence, Italy/IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
Azienda Ospedaliero-Universitaria Careggi · ITDon Carlo Gnocchi Foundation · ITSorbonne Université · FRTUM Klinikum · DEUniversity Hospital of Basel · CHUniversity of Florence · ITUniversity of Warmia and Mazury in Olsztyn · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe spread of Coronavirus disease-19 (COVID-19) poses unique challenges in the management of people with multiple sclerosis (PwMS).

objectivesTo collect data about the impact of COVID-19 emergency on access to care for PwMS and on MS treatment practices.

methodsBetween March and July 2020, the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) promoted an online survey covering patient access to care, management of relapses and visits, disease-modifying therapy (DMT) and experience with COVID-19.

resultsThree-hundred and sixty neurologists from 52 countries (68% from Europe) completed the survey. 98% reported COVID-19-related restrictions. Telemedicine was adopted to overcome the limited access to care and was newly activated (73%) or widely implemented (17%). 70% reported changes in DMT management. Interferons and glatiramer were considered safe. Dimethyl fumarate, teriflunomide and fingolimod were considered safe except for patients developing lymphopenia. No modifications were considered for natalizumab in 64%, cladribine in 24%, anti-CD20 in 22% and alemtuzumab in 17%; 18% (for alemtuzumab and cladribine) and 43% (for anti-CD20) considered postponing treatment.

conclusionThe ECTRIMS survey highlighted the challenges in keeping standards of care in clinical practice. Telemedicine clearly needs to be implemented. Gathering data on DMT safety will remain crucial to inform treatment decisions.

Indexed as

COVID-19Multiple SclerosisMultiple Sclerosis, Relapsing-RemittingFingolimod HydrochlorideHumansImmunosuppressive AgentsSARS-CoV-2Fingolimod HydrochlorideImmunosuppressive Agentsaccess to careCoronavirus disease-19disease-modifying treatmentMultiple sclerosistelemedicine

Identifiers

PMID33764197
PMCPMC8689421
OpenAlexW3137873237

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.