Evidence map›Paper›PMID 33763953›Full record

ArticleJournal of intellectual disability research : JIDR2022

Evaluating working memory outcome measures for children with Down syndrome.

E K Schworer, A J Esbensen, D J Fidler, D W Beebe, A Carle, S Wiley

Open access · greenAbstract read
In one paragraph

Article in Journal of intellectual disability research : JIDR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
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  8. A Review of Clinical Trials in Down Syndrome.International review of research in developmental disabilities · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Psychometric properties of inhibitory control measures among youth with Down syndrome.Journal of intellectual disability research : JIDR · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Evaluating Verbal Fluency Outcome Measures in Children With Down Syndrome.American journal on intellectual and developmental disabilities · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

E K SchworerDivision of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-5309-339X
A J EsbensenDivision of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0003-2649-7791
D J FidlerHuman Development and Family Studies, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0001-6208-456X
D W BeebeDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
A CarleDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
S WileyDivision of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Cincinnati Children's Hospital Medical Center · USColorado State University · US

Funding

INCLUDE19 – Evaluating outcome measures in young adults with Down syndromeR01HD093754 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Anna J. Esbensen · 2018 to 2026
$6.2M
NICHD NIH HHS R01 HD093754
6 · The paper itself

Abstract

backgroundThere is a critical need for the psychometric evaluation of outcome measures to be used in clinical trials targeting cognition in Down syndrome (DS). This study examines a specific cognitive skill that is of particular importance in DS, working memory, and the psychometric properties of a set of standardised measurements to assess working memory in individuals with DS.

methodsNinety children and adolescents ages 6 to 18 years old with DS were assessed on a selection of verbal and visuospatial working memory subtests of standardised clinical assessments at two time points to examine feasibility, distributional qualities, test-retest reliability and convergent validity against a priori criteria. Caregivers also completed an adaptive behaviour questionnaire to address working memory subtests' associations with broader developmental functioning.

resultsThe Stanford Binet-5 Verbal Working Memory, Differential Ability Scales-2 Recognition of Pictures, Stanford Binet-5 Nonverbal Working Memory and Wechsler Intelligence Scale for Children-5 Picture Span measures met the most psychometric criteria overall across the full age and IQ range of the study. Although Differential Ability Scales-2 Recall of Sequential Order and Differential Ability Scales-2 Recall of Digits Backward met the fewest a priori criteria, follow-up analyses suggested greater feasibility in specific age and IQ ranges.

conclusionsSeveral working memory measures appear to be psychometrically sound and appropriate for use in clinical trials for children with DS, especially when focusing on raw scores. However, floor effects on standard scores and feasibility of some measures were problematic. Guidelines for use of the working memory subtests with this population are provided.

Indexed as

Down SyndromeMemory, Short-TermAdolescentChildHumansOutcome Assessment, Health CareReproducibility of ResultsWechsler Scaleschildrenclinical trialsDown syndromemeasurementworking memory

Identifiers

PMID33763953
PMCPMC8463631
OpenAlexW3135930466

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.