ArticleGeroScience2021
Lifelong exercise is associated with more homogeneous motor unit potential features across deep and superficial areas of vastus lateralis.
Article in GeroScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Shatavari supplementation in postmenopausal women alters the skeletal muscle proteome and pathways involved in training adaptation.European journal of nutrition · 2024Trial
- Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans.Experimental physiology · 2026Article
- Bilateral neuromuscular adaptation to acute unilateral resistance exercise in healthy older adults.GeroScience · 2025Article
- Neuromuscular adaptations in soleus and tibialis anterior muscles in persons with spinal cord injury.Journal of neuroengineering and rehabilitation · 2025Article
- Creatine monohydrate supplementation for older adults and clinical populations.Journal of the International Society of Sports Nutrition · 2025Review
- Motor unit adaptation to disuse: crossing the threshold from firing rate suppression to neuromuscular junction transmission.The Journal of physiology · 2025Review
- Muscle fibroblasts and stem cells stimulate motor neurons in an age and exercise-dependent manner.Aging cell · 2025Article
- Sex disparities of human neuromuscular decline in older humans.The Journal of physiology · 2025Article
- Multi-channel EMG manifestations of upper-extremity muscle coordination imbalance among community-dwelling sarcopenic seniors.Biomedical engineering online · 2024Article
- Skeletal muscle dysfunction with advancing age.Clinical science (London, England : 1979) · 2024Review
- Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults.GeroScience · 2024Article
- Menstrual Cycle Associated Alteration of Vastus Lateralis Motor Unit Function.Sports medicine - open · 2023Article
- Acute adaptation of central and peripheral motor unit features to exercise-induced fatigue differs with concentric and eccentric loading.Experimental physiology · 2023Article
- Three-dimensional mapping of ultrasound-derived skeletal muscle shear wave velocity.Frontiers in bioengineering and biotechnology · 2023Article
- Motor unit dysregulation following 15 days of unilateral lower limb immobilisation.The Journal of physiology · 2022Article
- Effects of short-term unloading and active recovery on human motor unit properties, neuromuscular junction transmission and transcriptomic profile.The Journal of physiology · 2022Article
- Aging and Possible Benefits or Negatives of Lifelong Endurance Running: How Master Male Athletes Differ from Young Athletes and Elderly Sedentary?International journal of environmental research and public health · 2022Article
- Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability.Experimental physiology · 2022Article
- Neuromuscular recruitment strategies of the vastus lateralis according to sex.Acta physiologica (Oxford, England) · 2022Article
- Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men.GeroScience · 2022Article
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8 authors.
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Abstract
Motor unit (MU) expansion enables rescue of denervated muscle fibres helping to ameliorate age-related muscle atrophy, with evidence to suggest master athletes are more successful at this remodelling. Electrophysiological data has suggested MUs located superficially are larger than those located deeper within young muscle. However, the effects of ageing and exercise on MU heterogeneity across deep and superficial aspects of vastus lateralis (VL) remain unclear. Intramuscular electromyography was used to record individual MU potentials (MUPs) and near fibre MUPs (NFMs) from deep and superficial regions of the VL during 25% maximum voluntary contractions, in 83 males (15 young (Y), 17 young athletes (YA), 22 old (O) and 29 master athletes (MA)). MUP size and complexity were assessed using area and number of turns, respectively. Multilevel mixed effects linear regression models were performed to investigate the effects of depth in each group. MUP area was greater in deep compared with superficial MUs in Y (p<0.001) and O (p=0.012) but not in YA (p=0.071) or MA (p=0.653). MUP amplitude and NF MUP area were greater, and MUPs were more complex in deep MUPs from Y, YA and O (all p<0.05) but did not differ across depth in MA (all p>0.07). These data suggest MU characteristics differ according to depth within the VL which may be influenced by both ageing and exercise. A more homogenous distribution of MUP size and complexity across muscle depths in older athletes may be a result of a greater degree of age-related MU adaptations.
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