Evidence map›Paper›PMID 33763470›Full record

Trial reportBioMed research international2021

ABCA1-Labeled Exosomes in Serum Contain Higher MicroRNA-193b Levels in Alzheimer's Disease.

Chen-Geng Liu, Yue Zhao, Yao Lu, Pei-Chang Wang

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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  11. Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chen-Geng LiuClinical Laboratory of Xuanwu Hospital, Capital Medical University, Beijing 100053, China.ORCID https://orcid.org/0000-0003-1455-8171
Yue ZhaoClinical Laboratory of Xuanwu Hospital, Capital Medical University, Beijing 100053, China.ORCID https://orcid.org/0000-0003-3651-0101
Yao LuClinical Laboratory of Xuanwu Hospital, Capital Medical University, Beijing 100053, China.ORCID https://orcid.org/0000-0002-3310-0759
Pei-Chang WangClinical Laboratory of Xuanwu Hospital, Capital Medical University, Beijing 100053, China.ORCID https://orcid.org/0000-0002-7970-9797
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to establish a method to determine whether microRNA-193b (miR-193b) levels in ABCA1-labeled serum exosomes might serve as a marker for the diagnosis of Alzheimer's disease.

methodsWe used immunocapture methods to determine the levels of ABCA1-labeled exosomal miR-193b in cultures of white blood cells (WBCs), red blood cells (RBCs), mouse hippocampal neuron HT-22 cells, and primary mouse neuronal cells. ABCA1-labeled exosomal miR-193b levels were also evaluated in the cerebrospinal fluid (CSF) and serum of APP/PS1 double-transgenic mice, as well as control subjects (

resultsABCA1 levels of exosomes harvested from the medium of HT-22 cells and neurons were significantly higher than those of RBCs and WBCs (

conclusionThis study provides a method to capture specific exosomes. Detection of serum exosomes labeled with ABCA1 may facilitate the early diagnosis of AD.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseATP Binding Cassette Transporter 1BiomarkersCell Line, TumorExosomesFemaleHumansMaleMicroRNAsMiddle AgedABCA1 protein, humanATP Binding Cassette Transporter 1BiomarkersMicroRNAsMIRN193 microRNA, human

Identifiers

PMID33763470
PMCPMC7963893
OpenAlexW3133625973

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.