Evidence map›Paper›PMID 33763441›Full record

ReviewFrontiers in nutrition2021

Is There an Exercise-Intensity Threshold Capable of Avoiding the Leaky Gut?

Filipe M Ribeiro, Bernardo Petriz, Gabriel Marques, Lima H Kamilla, Octavio L Franco

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 6 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 6 syntheses or guidelines pooled it, 109 citations in OpenAlex.

  1. Pooled it
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  4. Effect of Intensity and Duration of Exercise on Gut Microbiota in Humans: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
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  9. Exercise intensity and training alter the innate immune cell type and chromosomal origins of circulating cell-free DNA in humans.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Trial
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  13. Review
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  18. Photobiomodulation Strengthens Muscles via Its Dual Functions in Gut Microbiota.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Filipe M RibeiroPost-graduation Program in Physical Education, Catholic University of Brasilia, Brasilia, Brazil.
Bernardo PetrizCenter for Proteomic and Biochemical Analysis, Post-graduation in Genomic and Biotechnology Sciences, Catholic University of Brasilia, Brasília, Brazil.
Gabriel MarquesLaboratory of Molecular Exercise Physiology, University Center - UDF, Brasilia, Brazil.
Lima H KamillaCenter for Proteomic and Biochemical Analysis, Post-graduation in Genomic and Biotechnology Sciences, Catholic University of Brasilia, Brasília, Brazil.
Octavio L FrancoPost-graduation Program in Physical Education, Catholic University of Brasilia, Brasilia, Brazil.
Universidade Católica de Brasília · BRBiotech (Brazil) · BRCentro Universitário do Distrito Federal · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endurance-sport athletes have a high incidence of gastrointestinal disorders, compromising performance and impacting overall health status. An increase in several proinflammatory cytokines and proteins (LPS, I-FABP, IL-6, IL-1β, TNF-α, IFN-γ, C-reactive protein) has been observed in ultramarathoners and triathlon athletes. One of the most common effects of this type of physical activity is the increase in intestinal permeability, known as leaky gut. The intestinal mucosa's degradation can be identified and analyzed by a series of molecular biomarkers, including the lactulose/rhamnose ratio, occludin and claudin (tight junctions), lipopolysaccharides, and I-FABP. Identifying the molecular mechanisms involved in the induction of leaky gut by physical exercise can assist in the determination of safe exercise thresholds for the preservation of the gastrointestinal tract. It was recently shown that 60 min of vigorous endurance training at 70% of the maximum work capacity led to the characteristic responses of leaky gut. It is believed that other factors may contribute to this effect, such as altitude, environmental temperature, fluid restriction, age and trainability. On the other hand, moderate physical training and dietary interventions such as probiotics and prebiotics can improve intestinal health and gut microbiota composition. This review seeks to discuss the molecular mechanisms involved in the intestinal mucosa's adaptation and response to exercise and discuss the role of the intestinal microbiota in mitigating these effects.

Indexed as

exercise thresholdgastrointestinal disordergut injurygut microbiotaleaky gut

Identifiers

PMID33763441
PMCPMC7982409
OpenAlexW3135095184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.