Evidence map›Paper›PMID 33763229›Full record

ArticleClinical & translational immunology2021

Memory CD8

Claire Loiseau, Boubacar Traore, Aissata Ongoiba, Kassoum Kayentao, Safiatou Doumbo, Didier Doumtabe, Karina P de Sousa, Jamie L Brady, Carla Proietti, Peter D Crompton and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical & translational immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Claire LoiseauCentre for Molecular Therapeutics Australian Institute of Tropical Health and Medicine James Cook University Cairns QLD Australia.ORCID https://orcid.org/0000-0003-4504-5635
Boubacar TraoreMali International Center of Excellence in Research University of Sciences, Technique and Technology of Bamako Bamako Mali.
Aissata OngoibaMali International Center of Excellence in Research University of Sciences, Technique and Technology of Bamako Bamako Mali.
Kassoum KayentaoMali International Center of Excellence in Research University of Sciences, Technique and Technology of Bamako Bamako Mali.
Safiatou DoumboMali International Center of Excellence in Research University of Sciences, Technique and Technology of Bamako Bamako Mali.
Didier DoumtabeMali International Center of Excellence in Research University of Sciences, Technique and Technology of Bamako Bamako Mali.
Karina P de SousaCentre for Molecular Therapeutics Australian Institute of Tropical Health and Medicine James Cook University Cairns QLD Australia.ORCID https://orcid.org/0000-0002-1418-0669
Jamie L BradyCentre for Molecular Therapeutics Australian Institute of Tropical Health and Medicine James Cook University Cairns QLD Australia.
Carla ProiettiCentre for Molecular Therapeutics Australian Institute of Tropical Health and Medicine James Cook University Cairns QLD Australia.
Peter D CromptonMalaria Infection Biology and Immunity Section Laboratory of Immunogenetics National Institute of Allergy and Infectious Diseases National Institutes of Health Rockville MD USA.ORCID https://orcid.org/0000-0001-5629-0412
Denise L DoolanCentre for Molecular Therapeutics Australian Institute of Tropical Health and Medicine James Cook University Cairns QLD Australia.ORCID https://orcid.org/0000-0001-7354-8817
Australian Institute of Tropical Health and Medicine · AUUniversity of Bamako · MLNational Institutes of Health · US

Funding

Mechanisms of naturally-acquired immunity to malaria and clinical trials of anti-malaria monoclonal antibodiesZIAAI001155 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CROMPTON, PETER · 2011 to 2025
$30.9M
6 · The paper itself

Abstract

objectivesStudy of individuals with protection from

methodsSubsets of memory T cells and NK cells were analysed by flow cytometry in paired samples collected from HbAS and HbAA children, at baseline and during the first malaria episode of the ensuing transmission season. Correlations between cell frequencies and features of HbAS-mediated protection from malaria were determined.

resultsHbAS children displayed significantly higher frequency of memory CD8

conclusionThis study shows that HbAS children develop a larger memory CD8

Indexed as

haemoglobin ASmemory CD8+ T cellsPlasmodium falciparumprotective immunitysickle‐cell trait phenotype

Identifiers

PMID33763229
PMCPMC7979311
OpenAlexW3136639210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.