Evidence map›Paper›PMID 33763067›Full record

ArticleFrontiers in immunology2021

Generation of Transgenic Mice that Conditionally Overexpress Tenascin-C.

Saori Yonebayashi, Kazuko Tajiri, Mari Hara, Hiromitsu Saito, Noboru Suzuki, Satoshi Sakai, Taizo Kimura, Akira Sato, Akiyo Sekimoto, Satoshi Fujita and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Tenascin-C in Tissue Repair after Myocardial Infarction in Humans.International journal of molecular sciences · 2023
    Article
  5. Article
  6. Advances on the roles of tenascin-C in cancer.Journal of cell science · 2022
    Article
  7. Tenascin-C in fibrosis in multiple organs: Translational implications.Seminars in cell & developmental biology · 2022
    Review
  8. Tenascin-C induction exacerbates post-stroke brain damage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  9. The Role of Matrix Proteins in Cardiac Pathology.International journal of molecular sciences · 2022
    Review
  10. Tenascin-C in Heart Diseases-The Role of Inflammation.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Saori YonebayashiDepartment of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Kazuko TajiriDepartment of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Mari HaraDepartment of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Tsu, Japan.
Hiromitsu SaitoDepartment of Animal Genomics, Functional Genomics Institute, Mie University Life Science Research Center, Tsu, Japan.
Noboru SuzukiDepartment of Animal Genomics, Functional Genomics Institute, Mie University Life Science Research Center, Tsu, Japan.
Satoshi SakaiDepartment of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Taizo KimuraDepartment of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Akira SatoDepartment of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Akiyo SekimotoDepartment of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Tsu, Japan.
Satoshi FujitaDepartment of Cardiology, Graduate School of Medicine, Mie University, Tsu, Japan.
Ryuji OkamotoDepartment of Cardiology, Graduate School of Medicine, Mie University, Tsu, Japan.
Robert J SchwartzDepartment of Biology and Biochemistry, University of Houston, Houston, TX, United States.
Toshimichi YoshidaDepartment of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Tsu, Japan.
Kyoko Imanaka-YoshidaDepartment of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Tsu, Japan.
Mie University · JPUniversity of Tsukuba · JPUniversity of Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tenascin-C (TNC) is an extracellular matrix glycoprotein that is expressed during embryogenesis. It is not expressed in normal adults, but is up-regulated under pathological conditions. Although TNC knockout mice do not show a distinct phenotype, analyses of disease models using TNC knockout mice combined with

Indexed as

AnimalsChromosome WalkingCytokinesGene Expression Regulation, DevelopmentalGenomeHomozygoteInflammation MediatorsIntegrasesMiceMice, Inbred C57BLMice, TransgenicMyocardial InfarctionNeurodegenerative DiseasesPhenotypePromoter Regions, GeneticTenascinCre recombinaseCytokinesInflammation MediatorsIntegrasesTenascinVentricular Myosinsalpha myosin heavy chainAtp8a2Cre-Loxheart developmentmatricellular proteinmyocardial inafrctionNkx2.5

Identifiers

PMID33763067
PMCPMC7982461
OpenAlexW3133575283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.