Evidence map›Paper›PMID 33763021›Full record

ReviewFrontiers in neurology2021

Multiparametric Quantitative MRI in Neurological Diseases.

Alexander Seiler, Ulrike Nöth, Pavel Hok, Annemarie Reiländer, Michelle Maiworm, Simon Baudrexel, Sven Meuth, Felix Rosenow, Helmuth Steinmetz, Marlies Wagner and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 75 citations in OpenAlex.

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  18. Quantitative MRI of the hippocampus reveals microstructural trajectories of aging and Alzheimer's disease pathology.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Alexander SeilerDepartment of Neurology, Goethe University, Frankfurt, Germany.
Ulrike NöthBrain Imaging Center, Goethe University, Frankfurt, Germany.
Pavel HokDepartment of Neurology, Palacký University Olomouc and University Hospital Olomouc, Olomouc, Czechia.
Annemarie ReiländerDepartment of Neurology, Goethe University, Frankfurt, Germany.
Michelle MaiwormDepartment of Neurology, Goethe University, Frankfurt, Germany.
Simon BaudrexelDepartment of Neurology, Goethe University, Frankfurt, Germany.
Sven MeuthDepartment of Neurology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Felix RosenowDepartment of Neurology, Goethe University, Frankfurt, Germany.
Helmuth SteinmetzDepartment of Neurology, Goethe University, Frankfurt, Germany.
Marlies WagnerBrain Imaging Center, Goethe University, Frankfurt, Germany.
Elke HattingenCenter for Personalized Translational Epilepsy Research (CePTER) Consortium, Goethe University, Frankfurt, Germany.
Ralf DeichmannBrain Imaging Center, Goethe University, Frankfurt, Germany.
René-Maxime GracienDepartment of Neurology, Goethe University, Frankfurt, Germany.
Goethe University Frankfurt · DEHeinrich Heine University Düsseldorf · DEUniversity Hospital Olomouc · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) is the gold standard imaging technique for diagnosis and monitoring of many neurological diseases. However, the application of conventional MRI in clinical routine is mainly limited to the visual detection of macroscopic tissue pathology since mixed tissue contrasts depending on hardware and protocol parameters hamper its application for the assessment of subtle or diffuse impairment of the structural tissue integrity. Multiparametric quantitative (q)MRI determines tissue parameters quantitatively, enabling the detection of microstructural processes related to tissue remodeling in aging and neurological diseases. In contrast to measuring tissue atrophy via structural imaging, multiparametric qMRI allows for investigating biologically distinct microstructural processes, which precede changes of the tissue volume. This facilitates a more comprehensive characterization of tissue alterations by revealing early impairment of the microstructural integrity and specific disease-related patterns. So far, qMRI techniques have been employed in a wide range of neurological diseases, including in particular conditions with inflammatory, cerebrovascular and neurodegenerative pathology. Numerous studies suggest that qMRI might add valuable information, including the detection of microstructural tissue damage in areas appearing normal on conventional MRI and unveiling the microstructural correlates of clinical manifestations. This review will give an overview of current qMRI techniques, the most relevant tissue parameters and potential applications in neurological diseases, such as early (differential) diagnosis, monitoring of disease progression, and evaluating effects of therapeutic interventions.

Indexed as

brain imagingepilepsymultiple sclerosisneurodegenerationneuroimagingquantitative magnetic resonance imaging

Identifiers

PMID33763021
PMCPMC7982527
OpenAlexW3134766823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.