Evidence map›Paper›PMID 33762943›Full record

ArticleFrontiers in pharmacology2021

Inhibition of Autophagy Prevents Panax Notoginseng Saponins (PNS) Protection on Cardiac Myocytes Against Endoplasmic Reticulum (ER) Stress-Induced Mitochondrial Injury, Ca

Jun Chen, Li Li, Xueyang Bai, Lili Xiao, Jiahong Shangguan, Wenjing Zhang, Xiangqin Zhang, Shen Wang, Gangqiong Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

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  19. Oxidative medicine and cellular longevity · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jun ChenVasculocardiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Li LiVasculocardiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xueyang BaiVasculocardiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lili XiaoVasculocardiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jiahong ShangguanVasculocardiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wenjing ZhangVasculocardiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiangqin ZhangVasculocardiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Shen WangVasculocardiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Gangqiong LiuVasculocardiology Department, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoplasmic reticulum (ER) stress is often closely linked to autophagy, hypoxia signaling, mitochondrial biogenesis and reactive oxygen species (ROS) responses. Understanding the interaction between ER stress, mitochondrial function and autophagy is of great importance to provide new mechanisms for the pathology, prevention and treatment of cardiovascular diseases. Our previous study has reported that Panax notoginseng saponins (PNS) protection against thapsigargin (TG)-induced ER stress response and associated cell apoptosis in cardiac myocytes is calcium dependent and mediated by ER Ca

Indexed as

apoptosisautophagyCa2+ homeostasisER stressmitochondrial injuryPNSROSRyR2 oxidation

Identifiers

PMID33762943
PMCPMC7982947
OpenAlexW3133704330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.