ArticleNeuro-ophthalmology (Aeolus Press)2021
Persistent Globe Flattening in Astronauts following Long-Duration Spaceflight.
Article in Neuro-ophthalmology (Aeolus Press), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- An eye on long-duration spaceflight: Controversies, countermeasures and challenges.Experimental physiology · 2026Review
- Spaceflight-associated neuro-ocular syndrome (SANS): expert consensus on diagnosis and management.Eye (London, England) · 2026Review
- Ophthalmic and Visual System Changes in Human Spaceflight: A Review of Mechanisms, Measurement, and Countermeasures.Journal of clinical medicine · 2026Review
- Optic nerve cerebrospinal fluid drainage via lymphatic vessels in its sheath.NPJ microgravity · 2026Article
- Optic nerve sheath diameter increases during 12Frontiers in physiology · 2026Article
- Dose-dependent reduction of optic nerve sheath diameter during graded lower body negative pressure in healthy adults of both sexes.Frontiers in network physiology · 2026Article
- Predicting Spaceflight-Associated Neuro-Ocular Syndrome in International Space Station Astronauts.JAMA ophthalmology · 2025Article
- Non invasive monitoring for spaceflight associated neuro ocular syndrome: responding to a need for In flight methodologies.NPJ microgravity · 2025Article
- Analysis of Spaceflight-Associated Biometric and Refractive Changes in Astronauts.American journal of ophthalmology · 2025Article
- Parabolic flight as a research platform to investigate ophthalmic changes in microgravity.Life sciences in space research · 2025Review
- Understanding the relationship between intracranial pressure and spaceflight associated neuro-ocular syndrome (SANS): a systematic review.NPJ microgravity · 2025Article
- Spaceflight Associated Neuro-ocular Syndrome (SANS) and its countermeasures.Progress in retinal and eye research · 2025Review
- A multifactorial, evidence-based analysis of pathophysiology in Spaceflight Associated Neuro-Ocular Syndrome (SANS).Eye (London, England) · 2025Review
- Intraocular Pressure and Retinal Nerve Fiber Layer Changes in a Microgravity Mouse Model and Relevance to Spaceflight-Associated Neuro-Ocular Syndrome.Eye and brain · 2025Article
- Hypothesis on the outflow of optic nerve cerebrospinal fluid in spaceflight associated neuro ocular syndrome.NPJ microgravity · 2024Review
- Refractive shifts in astronauts during spaceflight: mechanisms, countermeasures, and future directions for in-flight measurements.Eye (London, England) · 2024Article
- Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest.NPJ microgravity · 2024Article
- Quantitative ultrasound image assessment of the optic nerve subarachnoid space during 90-day head-down tilt bed rest.NPJ microgravity · 2024Article
- Exploring outer space biophysical phenomena via SpaceLID.Scientific reports · 2023Article
- Spaceflight associated neuro-ocular syndrome (SANS): an update on potential microgravity-based pathophysiology and mitigation development.Eye (London, England) · 2023Review
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Posterior globe flattening has been well-documented in astronauts both during and after long-duration space flight (LDSF) and has been observed as early as 10 days into a mission on the International Space Station. Globe flattening (GF) is thought to be caused by the disc centred anterior forces created by elevated volume and/or pressure within the optic nerve sheath (ONS). This might be the result of increased intracranial pressure, increased intraorbital ONS pressure from compartmentalisation or a combination of these mechanisms. We report posterior GF in three astronauts that has persisted for 7 years or more following their return from LDSFs suggesting that permanent scleral remodelling may have occurred.
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