Evidence map›Paper›PMID 33762776›Full record

ArticleIEEE journal of solid-state circuits2020

The Design of a CMOS Nanoelectrode Array with 4096 Current-Clamp/Voltage-Clamp Amplifiers for Intracellular Recording/Stimulation of Mammalian Neurons.

Jeffrey Abbott, Tianyang Ye, Keith Krenek, Ling Qin, Youbin Kim, Wenxuan Wu, Rona S Gertner, Hongkun Park, Donhee Ham

Abstract read
In one paragraph

Article in IEEE journal of solid-state circuits, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Single neurons on microelectrode array chip: manipulation and analyses.Frontiers in bioengineering and biotechnology · 2023
    Article
  10. Article
  11. Article
  12. Lab-on-Chip Microsystems forFrontiers in bioengineering and biotechnology · 2022
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jeffrey AbbottJohn A. Paulson School of Engineering and Applied Sciences, the Department of Chemistry and Chemical Biology, and the Department of Physics, Harvard University, Cambridge, MA 02138, USA.
Tianyang YeJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
Keith KrenekJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
Ling QinJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138 USA. He is now with Cavium Inc., Marlborough, MA 01752, USA.
Youbin KimHarvard College, Cambridge, MA 02138 USA. He is now with University of California, Berkeley, CA 94720, USA.
Wenxuan WuJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
Rona S GertnerDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Hongkun ParkDepartment of Chemistry and Chemical Biology and the Department of Physics, Harvard University, Cambridge, MA 02138 USA.
Donhee HamJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

Funding

Comprehensive Classification Of Neuronal Subtypes By Single Cell TranscriptomicsU01MH105960 · NIMH · HARVARD UNIVERSITY · PI REGEV, AVIV, SANES, JOSHUA R · 2014 to 2016
$4.5M
NIMH NIH HHS U01 MH105960
6 · The paper itself

Abstract

CMOS microelectrode arrays (MEAs) can record electrophysiological activities of a large number of neurons in parallel but only extracellularly with low signal-to-noise ratio. Patch clamp electrodes can perform intracellular recording with high signal-to-noise ratio but only from a few neurons in parallel. Recently we have developed and reported a neuroelectronic interface that combines the parallelism of the CMOS MEA and the intracellular sensitivity of the patch clamp. Here, we report the design and characterization of the CMOS integrated circuit (IC), a critical component of the neuroelectronic interface. Fabricated in 0.18-

Indexed as

current clampextracellular recordingintegrated circuitsintracellular recordingmicroelectrode arraynano-bio interfacenanoelectrode arrayneurobiologyneuronsswitched capacitorvoltage clamp

Identifiers

PMID33762776
PMCPMC7983016

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.