ArticleNature2021
Auto-aggressive CXCR6
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 311 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
311citing papers in PubMed, 2 pooled it
27.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
311 citing papers in PubMed, 2 syntheses or guidelines pooled it, 460 citations in OpenAlex.
- Global prevalence of metabolic dysfunction-associated fatty liver disease-related hepatocellular carcinoma: A systematic review and meta-analysis.Clinical and molecular hepatology · 2024Pooled it
- Pooled it
- Mixed active metabolites of the SNP-6 series of novel compounds mitigate metabolic dysfunction-associated steatohepatitis and fibrosis: promising results from pre-clinical and clinical trials.Journal of translational medicine · 2024Trial
- Gut microbiota shaping fatty liver disease progression.Life science alliance · 2027Review
- Molecular mechanisms and pathogenesis of MASH.Nature · 2026Review
- The Emerging Challenge of Non-Cirrhotic MASLD-Related Hepatocellular Carcinoma: Etiology, Immunopathology, and Precision Oncology.Liver cancer · 2026Review
- Review
- Article
- Metabolically and epigenetically reprogrammed splenic TRNP1Nature genetics · 2026Article
- Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Intestinal FXR deficiency uncouples steatosis protection from liver inflammation and fibrosis in MASH-diet fed mice.Scientific reports · 2026Article
- Unleashing innovative cross-organ fibrosis therapies by harnessing the omics revolution.JCI insight · 2026Review
- Hepatic inflammation after exposure to a mixture of low-dose arsenic and cadmium in a murine model of fatty liver disease.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Ammonia in the crosshairs: microbial targets for metabolic dysfunction-associated steatohepatitis prevention.The Journal of clinical investigation · 2026Article
- IL15-mediated crosstalk between LSECs and CD8⁺ tissue-resident memory T cells drives alcohol-associated hepatitis.Hepatology communications · 2026Article
- Metabolic dysfunction-associated steatohepatitis exacerbated by Clostridium perfringens-derived ammonia is attenuated by tripeptide DT-109.The Journal of clinical investigation · 2026Article
- Depletion of NAT10 in T cells attenuates metabolic dysfunction-associated steatohepatitis in mice.Hepatology communications · 2026Article
- Immunosenescence in systemic and multi-organ aging: mechanisms, inter-organ crosstalk, and translational opportunities.npj aging · 2026Review
- When the Liver Flares: Inflammatory and Immunometabolic Mechanisms Driving the Transition from MASLD to MASH.Inflammation · 2026Review
- The versatile interplay between steatotic liver disease and liver cancer.Nature reviews. Cancer · 2026Review
251 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
48 authors at 15 institutions in 4 countries.
Michael DudekInstitute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
Dominik PfisterInstitute of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-0542-2638
Sainitin DonakondaInstitute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.ORCID http://orcid.org/0000-0003-3216-8759
Pamela FilpeDepartment of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Annika SchneiderInstitute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
Melanie LaschingerDepartment of Surgery, University Hospital München rechts der Isar, TUM, Munich, Germany.
Daniel HartmannDepartment of Surgery, University Hospital München rechts der Isar, TUM, Munich, Germany.
Norbert HüserDepartment of Surgery, University Hospital München rechts der Isar, TUM, Munich, Germany.
Philippa MeiserInstitute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
Felix BayerlInstitute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
Donato InversoDivision of Vascular Oncology and Metastasis, German Cancer ResearchCenter Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0987-3345
Jennifer WiggerDepartment of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Marcial SebodeDepartment of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Rupert ÖllingerInstitute of Molecular Oncology and Functional Genomics, TUM, Munich, Germany.
Roland RadInstitute of Molecular Oncology and Functional Genomics, TUM, Munich, Germany.ORCID http://orcid.org/0000-0002-6849-9659
Silke HegenbarthInstitute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
Martina AntonInstitute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.ORCID http://orcid.org/0000-0001-5290-5213
Adrien GuillotDepartment of Hepatology and Gastroenterology, Charité Universitätsmedizin, Berlin, Germany.ORCID http://orcid.org/0000-0002-6002-9986
Andrew BowmanMaastricht MultiModal Molecular Imaging (M4I) Institute, Division of Imaging Mass Spectrometry, Maastricht University, Maastricht, the Netherlands.ORCID http://orcid.org/0000-0002-7609-8687
Danijela HeideInstitute of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.
Florian MüllerInstitute of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.
Pierluigi RamadoriInstitute of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.
Valentina LeoneInstitute of Virology, Technical University Munich and Helmholtz Zentrum Munich, Munich, Germany.
Cristina Garcia-CaceresInstitute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.
Tim GruberInstitute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.
Gabriel SeifertDepartment of General and Visceral Surgery, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-3771-2186
Agnieszka M KabatMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID http://orcid.org/0000-0003-1916-5983
Jan-Philipp MallmDivision of Chromatin Networks, Single-cell Open Lab, German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7059-4030
Simon ReiderDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-0578-9843
Maria EffenbergerDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-0499-9953
Susanne RothDepartment of General, Visceral and Transplantation Surgery, Heidelberg University, Heidelberg, Germany.
Adrian T BilleterDepartment of General, Visceral and Transplantation Surgery, Heidelberg University, Heidelberg, Germany.
Beat Müller-StichDepartment of General, Visceral and Transplantation Surgery, Heidelberg University, Heidelberg, Germany.
Edward J PearceMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID http://orcid.org/0000-0003-1001-9656
Friedrich Koch-NolteInstitute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Rafael KäserDepartment of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Herbert TilgDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-4235-2579
Robert ThimmeDepartment of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-1417-4135
Tobias BoettlerDepartment of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-1195-055X
Frank TackeDepartment of Hepatology and Gastroenterology, Charité Universitätsmedizin, Berlin, Germany.
Jean-Francois DufourUniversity Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-8062-1346
Dirk HallerChair of Nutrition and Immunology, School of Life Sciences Weihenstephan, TUM, Freising, Germany.ORCID http://orcid.org/0000-0002-6977-4085
Peter J MurrayInstitute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
Ron HeerenMaastricht MultiModal Molecular Imaging (M4I) Institute, Division of Imaging Mass Spectrometry, Maastricht University, Maastricht, the Netherlands.ORCID http://orcid.org/0000-0002-6533-7179
Dietmar ZehnDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, TUM, Freising, Germany.ORCID http://orcid.org/0000-0003-1393-8527
Jan P BöttcherInstitute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.ORCID http://orcid.org/0000-0002-8163-8107
Mathias HeikenwälderInstitute of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-3135-2274
Percy A KnolleInstitute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany. percy.knolle@tum.de.ORCID http://orcid.org/0000-0003-2983-0414
German Cancer Research Center · DETechnical University of Munich · DEUniversität Hamburg · DEUniversity of Freiburg · DEHeidelberg University · DEHelmholtz Zentrum München · DEInnsbruck Medical University · ATTUM Klinikum · DEWeihenstephan-Triesdorf University of Applied Sciences · DECharité - Universitätsmedizin Berlin · DEMaastricht University · NLMax Planck Institute of Immunobiology and Epigenetics · DEGerman Center for Infection Research · DEMax Planck Institute of Biochemistry · DEUniversity of Bern · CH
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonalcoholic steatohepatitis (NASH) is a manifestation of systemic metabolic disease related to obesity, and causes liver disease and cancer
Indexed as
AcetatesAnimalsCD8-Positive T-LymphocytesCell DeathDiet, High-FatDisease Models, AnimalHumansInterleukin-15LiverMaleMiceMice, Inbred C57BLNon-alcoholic Fatty Liver DiseaseReceptors, CXCR6AcetatesCXCR6 protein, humanCxcr6 protein, mouseInterleukin-15Receptors, CXCR6
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.