Evidence map›Paper›PMID 33762733›Full record

ArticleNature2021

NASH limits anti-tumour surveillance in immunotherapy-treated HCC.

Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner and 100 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 820 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
820citing papers in PubMed, 3 pooled it
144.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

820 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,187 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  15. Impact of PD-1 Inhibitor Timing Relative to Locoregional Therapy on Outcomes in uHCC Treated With Lenvatinib-Based Triple Therapy.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  16. Review
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  19. Article
  20. Dynamics changes of spleen volume predict survival outcomes in unresectable hepatocellular carcinoma treated with tislelizumab plus lenvatinib.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article

760 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

110 authors at 20 institutions in 13 countries.

Dominik PfisterDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-0542-2638
Nicolás Gonzalo NúñezInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-3837-270X
Roser PinyolLiver Cancer Translational Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Liver Unit, Universitat de Barcelona, Barcelona, Spain.
Olivier GovaereTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.ORCID http://orcid.org/0000-0002-4426-6930
Matthias PinterDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Marta SzydlowskaDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4660-899X
Revant GuptaInternal Medicine I, University Hospital Tübingen, Faculty of Medicine, University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-0881-5074
Mengjie QiuDepartment of General, Visceral and Transplantation Surgery, Universitätsklinikum Heidelberg, Heidelberg, Germany.
Aleksandra DeczkowskaDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0003-0844-4346
Assaf WeinerDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Florian MüllerDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ankit SinhaExperimental Systems Immunology Laboratory, Max-Planck Institute of Biochemistry, Munich, Germany.
Ekaterina FriebelInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-1419-2376
Thomas EngleitnerCenter for Translational Cancer Research (TranslaTUM), Technical University Munich, Munich, Germany.
Daniela LenggenhagerDepartment of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-5382-9854
Anja MoncsekDepartment of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1191-5842
Danijela HeideDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kristin StirmDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jan KoslaDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Eleni KotsilitiDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Valentina LeoneDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Michael DudekInstitute of Molecular Immunology and Experimental Oncology, Technical University Munich, Munich, Germany.
Suhail YousufDepartment of General, Visceral and Transplantation Surgery, Universitätsklinikum Heidelberg, Heidelberg, Germany.
Donato InversoDivision of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0987-3345
Indrabahadur SinghDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ana TeijeiroCancer Cell Biology Programme, Growth Factors, Nutrients and Cancer Group, Spanish National Cancer Research Centre, CNIO, Madrid, Spain.
Florian CastetLiver Cancer Translational Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Liver Unit, Universitat de Barcelona, Barcelona, Spain.
Carla MontironiLiver Cancer Translational Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Liver Unit, Universitat de Barcelona, Barcelona, Spain.
Philipp K HaberMount Sinai Liver Cancer Program, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dina TiniakosTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
Pierre BedossaTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
Simon CockellBioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
Ramy YounesTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
Michele VaccaUniversity of Cambridge Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.ORCID http://orcid.org/0000-0002-1973-224X
Fabio MarraDipartimento di Medicina Sperimentale e Clinica, University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0001-8629-0878
Jörn M SchattenbergMetabolic Liver Research Program, I. Department of Medicine, University Medical Center Mainz, Mainz, Germany.
Michael AllisonLiver Unit, Department of Medicine, Cambridge Biomedical Research Centre, Cambridge University NHS Foundation Trust, Cambridge, UK.ORCID http://orcid.org/0000-0003-3677-3294
Elisabetta BugianesiDepartment of Medical Sciences, Division of Gastro-Hepatology, A.O. Città della Salute e della Scienza di Torino, University of Turin, Turn, Italy.
Vlad RatziuAssistance Publique-Hôpitaux de Paris, Hôpital Beaujon, University Paris-Diderot, Paris, France.
Tiziana PressianiMedical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center-IRCCS, Milan, Italy.
Antonio D'AlessioMedical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center-IRCCS, Milan, Italy.ORCID http://orcid.org/0000-0002-9164-3671
Nicola PersoneniMedical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center-IRCCS, Milan, Italy.ORCID http://orcid.org/0000-0002-7995-272X
Lorenza RimassaMedical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center-IRCCS, Milan, Italy.ORCID http://orcid.org/0000-0001-9957-3615
Ann K DalyTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
Bernhard ScheinerDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Katharina PomejDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-2807-3565
Martha M KirsteinDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Arndt VogelDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Markus Peck-RadosavljevicDepartment of Internal Medicine and Gastroenterology (IMuG), Hepatology, Endocrinology, Rheumatology and Nephrology including Centralized Emergency Department (ZAE), Klinikum Klagenfurt am Wörthersee, Klagenfurt, Austria.ORCID http://orcid.org/0000-0002-0597-2728
Florian HuckeDepartment of Internal Medicine and Gastroenterology (IMuG), Hepatology, Endocrinology, Rheumatology and Nephrology including Centralized Emergency Department (ZAE), Klinikum Klagenfurt am Wörthersee, Klagenfurt, Austria.
Fabian FinkelmeierDepartment of Gastroenterology, Hepatology and Endocrinology, University Hospital Frankfurt, Frankfurt, Germany.
Oliver WaidmannDepartment of Gastroenterology, Hepatology and Endocrinology, University Hospital Frankfurt, Frankfurt, Germany.
Jörg TrojanDepartment of Gastroenterology, Hepatology and Endocrinology, University Hospital Frankfurt, Frankfurt, Germany.
Kornelius SchulzeDepartment of Internal Medicine, Gastroenterology & Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Henning WegeDepartment of Internal Medicine, Gastroenterology & Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sandra KochDepartment of Internal Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Arndt WeinmannDepartment of Internal Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Marco BueterDepartment of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland.
Fabian RösslerDepartment of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland.
Alexander SiebenhünerDepartment of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Sara De DossoOncology Institute of Southern Switzerland, Bellinzona, Switzerland.
Jan-Philipp MallmDivision of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7059-4030
Viktor UmanskyClinical Cooperation Unit Dermato-Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Manfred JugoldCore Facility Small Animal Imaging, German Cancer Research Center Heidelberg, Heidelberg, Germany.
Tom LueddeDepartment of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Andrea SchietingerImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-3644-1687
Peter SchirmacherInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Brinda EmuDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hellmut G AugustinDivision of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7173-4242
Adrian BilleterDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Beat Müller-StichDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Hiroto KikuchiEdwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3601-8435
Dan G DudaEdwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7065-8797
Fabian KüttingDepartment of Gastroenterology and Hepatology, University of Cologne, Cologne, Germany.
Dirk-Thomas WaldschmidtDepartment of Gastroenterology and Hepatology, University of Cologne, Cologne, Germany.
Matthias Philip EbertDepartment of Medicine II, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Nuh RahbariDepartment of Surgery at University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Henrik E MeiMass Cytometry Lab, Deutsches Rheumaforschungszentrum Berlin, a Leibniz Institute, Berlin, Germany.ORCID http://orcid.org/0000-0003-0697-7755
Axel Ronald SchulzMass Cytometry Lab, Deutsches Rheumaforschungszentrum Berlin, a Leibniz Institute, Berlin, Germany.ORCID http://orcid.org/0000-0002-5106-0148
Marc RingelhanInstitute of Virology, Technical University Munich/Helmholtz Zentrum Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-3131-5657
Nisar MalekMedical University Hospital Department of Internal Medicine I, Tübingen, Germany.
Stephan SpahnMedical University Hospital Department of Internal Medicine I, Tübingen, Germany.
Michael BitzerMedical University Hospital Department of Internal Medicine I, Tübingen, Germany.
Marina Ruiz de GalarretaMount Sinai Liver Cancer Program, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Amaia LujambioMount Sinai Liver Cancer Program, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-2798-1481
Jean-Francois DufourUniversity Clinic for Visceral Surgery and Medicine, Inselspital, Bern, Switzerland.ORCID http://orcid.org/0000-0002-8062-1346
Thomas U MarronMount Sinai Liver Cancer Program, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ahmed KasebDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Masatoshi KudoDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-, Sayama, Japan.ORCID http://orcid.org/0000-0002-4102-3474
Yi-Hsiang HuangInstitute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Nabil DjouderCancer Cell Biology Programme, Growth Factors, Nutrients and Cancer Group, Spanish National Cancer Research Centre, CNIO, Madrid, Spain.ORCID http://orcid.org/0000-0001-8423-1030
Katharina WolterDepartment of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen, Germany.
Lars ZenderDepartment of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0001-7626-2849
Parice N MarcheUniversité Grenoble Alpes, Grenoble, France.
Thomas DecaensUniversité Grenoble Alpes, Grenoble, France.
David J PinatoDepartment of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.ORCID http://orcid.org/0000-0002-3529-0103
Roland RadCenter for Translational Cancer Research (TranslaTUM), Technical University Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-6849-9659
Joachim C MertensDepartment of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-2007-0308
Achim WeberDepartment of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-0073-3637
Kristian UngerResearch Unit of Radiation Cytogenetics, Helmholtz Zentrum Munich, Munich, Germany.
Felix MeissnerExperimental Systems Immunology Laboratory, Max-Planck Institute of Biochemistry, Munich, Germany.ORCID http://orcid.org/0000-0003-1000-7989
Susanne RothDepartment of General, Visceral and Transplantation Surgery, Universitätsklinikum Heidelberg, Heidelberg, Germany.
Zuzana Macek JilkovaUniversité Grenoble Alpes, Grenoble, France.
Manfred ClaassenInternal Medicine I, University Hospital Tübingen, Faculty of Medicine, University of Tübingen, Tübingen, Germany.
Quentin M AnsteeTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.
Ido AmitDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0003-2968-877X
Percy KnolleInstitute of Molecular Immunology and Experimental Oncology, Technical University Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-2983-0414
Burkhard BecherInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1541-7867
Josep M LlovetLiver Cancer Translational Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Liver Unit, Universitat de Barcelona, Barcelona, Spain. jmllovet@clinic.cat.ORCID http://orcid.org/0000-0003-0547-2667
Mathias HeikenwalderDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. m.heikenwaelder@dkfz-heidelberg.de.ORCID http://orcid.org/0000-0002-3135-2274
German Cancer Research Center · DEHeidelberg University · DEUniversity Hospital of Zurich · CHUniversity of Zurich · CHHumanitas University · ITNewcastle University · GBCentre National de la Recherche Scientifique · FRConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESGoethe University Frankfurt · DEIcahn School of Medicine at Mount Sinai · USJohannes Gutenberg University Mainz · DEMedical University of Vienna · ATUniversity Children's Hospital Tübingen · DEWeizmann Institute of Science · ILGerman Rheumatism Research Centre · DEKlinikum Klagenfurt · ATMassachusetts General Hospital · USMedizinische Hochschule Hannover · DESpanish National Cancer Research Centre · ESTUM Klinikum · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4M
Tumor-intrinsic signaling pathways restrict anti-tumor immunity in hepatocellular carcinomaR37CA230636 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LUJAMBIO, AMAIA · 2018 to 2024
$2.7M
Cancer Research UK 26813NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA196521NCI NIH HHS R37 CA230636Wellcome Trust
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) can have viral or non-viral causes

Indexed as

ImmunotherapyAnimalsB7-H1 AntigenCarcinogenesisCarcinoma, HepatocellularCD8-Positive T-LymphocytesDisease ProgressionHumansLiverLiver NeoplasmsMaleMiceNon-alcoholic Fatty Liver DiseaseProgrammed Cell Death 1 ReceptorTumor Necrosis Factor-alphaB7-H1 AntigenCD274 protein, humanPDCD1 protein, humanProgrammed Cell Death 1 ReceptorTumor Necrosis Factor-alpha

Identifiers

PMID33762733
PMCPMC8046670
OpenAlexW3138484572

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.