ArticleNature2021
Breast tumours maintain a reservoir of subclonal diversity during expansion.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.
0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed
19.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
142 citing papers in PubMed, 275 citations in OpenAlex.
- Article
- A single-cell lens into the co-evolution of genotypes and phenotypes in cancer.Nature reviews. Cancer · 2026Review
- A medium throughput approach for single cell copy number variation sequencing towards efficient application in clinics.Journal of advanced research · 2026Article
- CNVeil resolves haplotype-specific copy number and uncovers subclonal architecture hidden from total copy number profiling in single-cell cancer genomes.bioRxiv : the preprint server for biology · 2026Article
- Geospatial genetic evolution and phenotypic plasticity in triple-negative breast cancer.Genome medicine · 2026Article
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- Dynamic uterine microenvironment drives endometrial adenocarcinoma carcinogenesis and progression.Communications biology · 2026Article
- tugMedi: simulator of cancer-cell evolution for personalized medicine based on the genomic data of patients.NPJ systems biology and applications · 2026Article
- Inferring tumor absolute copy number and clonal substructure from single-cell chromatin accessibility.Briefings in bioinformatics · 2026Article
- Integrated Single-Cell Whole-Genome Sequencing and Spatial Transcriptomics Reveal Intratumoral Heterogeneity in Ovarian Cancer.Cancer research communications · 2026Article
- Review
- Genome-wide biomarker analysis across the full spectrum of HER2-expressing breast cancers to reveal a clonal chromosome 17 imbalance defining unfavourable HER2-low disease.Biomarker research · 2026Article
- Impact of Chromosomal Instability and Aneuploidy in Cancer Development.Annual review of cancer biology · 2026Article
- Single-cell and spatial profiling in cancer biology and clinical oncology.Nature cancer · 2026Review
- Human iPSC-derived and conventional cancer models in precision oncology: advancing patient-specific therapies from bench to bedside.Journal of experimental & clinical cancer research : CR · 2026Review
- Cell confinement initiates a delayed but heritable loss of chromosomes.Cell reports · 2026Article
- DeepGene-BC: Deep Learning-Based Breast Cancer Subtype Prediction via Somatic Point Mutation Profiles.Cancers · 2026Article
- Cell confinement initiates a delayed but heritable loss of chromosomes.bioRxiv : the preprint server for biology · 2026Article
- CNAScope: pan-cancer copy number aberration database with functional annotation and interactive visualization.Nucleic acids research · 2026Article
- Benchmarking Ploidy Estimation Methods for Bulk and Single-Cell Whole Genome Sequencing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 4 institutions in 2 countries.
Darlan C Minussi *Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Michael D Nicholson *Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
Hanghui Ye *Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-9179-7577
Alexander DavisDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kaile WangDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Toby BakerCancer Genomics Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-5183-9047
Maxime TarabichiCancer Genomics Laboratory, The Francis Crick Institute, London, UK.
Emi SeiDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Haowei DuDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-9052-1587
Mashiat RabbaniDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Cheng PengDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Min HuDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Shanshan BaiDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yu-Wei LinDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Aislyn SchalckDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Asha MultaniDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jin MaDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Thomas O McDonaldDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
Anna CasasentDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Angelica BarreraDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hui ChenDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Bora LimDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-4182-6058
Banu ArunDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Funda Meric-BernstamDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Peter Van LooCancer Genomics Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-0292-1949
Franziska MichorDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA. michor@jimmy.harvard.edu.ORCID http://orcid.org/0000-0003-4869-8842
Nicholas E NavinDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. nnavin@mdanderson.org.ORCID http://orcid.org/0000-0002-2106-8624
The University of Texas MD Anderson Cancer Center · USThe Francis Crick Institute · GBHarvard University · USBroad Institute · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8MThe Cell-Of-Origin of Human CancersU54CA143798 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI MICHOR, FRANZISKA · 2009 to 2014
$11.2MDELINEATING THE EVOLUTION AND ECOLOGY OF CHEMORESISTANCE IN BREAST CANCER WITH SINGLE CELL GENOMICSR01CA236864 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NAVIN, NICHOLAS · 2020 to 2024
$2.3MINVESTIGATING TUMOR INITIATION AND INVASION IN PREMALIGNANT BREAST CANCER WITH SPATIAL SINGLE CELL GENOMICSR01CA240526 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NAVIN, NICHOLAS · 2019 to 2023
$1.8MNCI NIH HHS P30 CA016672NCI NIH HHS R01 CA236864NCI NIH HHS R01 CA240526NCI NIH HHS U54 CA143798Wellcome Trust FC001202
Abstract
Our knowledge of copy number evolution during the expansion of primary breast tumours is limited
Indexed as
Cell ProliferationEvolution, MolecularBase SequenceBreast NeoplasmsCell LineageCell Line, TumorChromosome AberrationsClone CellsDNA Copy Number VariationsDNA Mutational AnalysisGenomic InstabilityHumansLoss of HeterozygosityModels, GeneticMutation RateSingle-Cell Analysis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.