Evidence map›Paper›PMID 33762660›Full record

ArticleScientific reports2021

Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.

Leonardo Capistrano Ferreira, Carlos Eduardo Maia Gomes, Priya Duggal, Ingrid De Paula Holanda, Amanda Samara de Lima, Paulo Ricardo Porfírio do Nascimento, Selma Maria Bezerra Jeronimo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Leonardo Capistrano FerreiraDepartment of Biochemistry, Center of Biosciences, Federal University of Rio Grande do Norte, Av. Sen. Salgado Filho, S/N, Campus Universitário - Lagoa Nova, Natal, RN, 59078-900, Brazil. ferreiralc@cb.ufrn.br.
Carlos Eduardo Maia GomesDepartment of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Brazil.
Priya DuggalBloomberg School of Public Health, Johns Hopkins University, Baltimore, USA.
Ingrid De Paula HolandaDepartment of Biochemistry, Federal University of Rio Grande do Norte, Natal, Brazil.
Amanda Samara de LimaMaternidade Escola Januario Cicco, Federal University of Rio Grande do Norte, Natal, Brazil.
Paulo Ricardo Porfírio do NascimentoInstitute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, Natal, Brazil.
Selma Maria Bezerra JeronimoInstitute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, Natal, Brazil.
Universidade Federal do Rio Grande do Norte · BRJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical spectrum of hypertensive disorders of pregnancy (HDP) is determined by the interplay between environmental and genetic factors, most of which remains unknown. ERAP1, ERAP2 and LNPEP genes code for multifunctional aminopeptidases involved with antigen processing and degradation of small peptides such as angiotensin II (Ang II), vasopressin and oxytocin. We aimed to test for associations between genetic variants in aminopeptidases and HDP. A total of 1282 pregnant women (normotensive controls, n = 693; preeclampsia, n = 342; chronic hypertension with superimposed preeclampsia, n = 61; eclampsia, n = 74; and HELLP syndrome, n = 112) were genotyped for variants in LNPEP (rs27300, rs38034, rs2303138), ERAP1 (rs27044, rs30187) and ERAP2 (rs2549796 rs2927609 rs11135484). We also evaluated the effect of ERAP1 rs30187 on plasma Ang II levels in an additional cohort of 65 pregnant women. The genotype C/C, in ERAP1 rs30187 variant (c.1583 T > C, p.Lys528Arg), was associated with increased risk of eclampsia (OR = 1.85, p = 0.019) whereas ERAP2 haplotype rs2549796(C)-rs2927609(C)-rs11135484(G) was associated with preeclampsia (OR = 1.96, corrected p-value = 0.01). Ang II plasma levels did not differ across rs30187 genotypic groups (p = 0.895). In conclusion, ERAP1 gene is associated with eclampsia whereas ERAP2 is associated with preeclampsia, although the mechanism by which genetic variants in ERAPs influence the risk of preeclampsia and eclampsia remain to be elucidated.

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseAllelesAminopeptidasesBrazilEclampsiaFemaleGene FrequencyGenotypeHaplotypesHELLP SyndromeHumansLinkage DisequilibriumMinor Histocompatibility AntigensModels, GeneticOdds RatioAminopeptidasesERAP1 protein, humanERAP2 protein, humanMinor Histocompatibility Antigens

Identifiers

PMID33762660
PMCPMC7990956
OpenAlexW3135235276

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.