ArticleScientific reports2021
Comparative in silico genome analysis of Clostridium perfringens unravels stable phylogroups with different genome characteristics and pathogenic potential.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 35 citations in OpenAlex.
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- Mixture dependent correlation patterns in antibacterial and cytotoxic activities of five hop isolates.Scientific reports · 2026Article
- Genomic and clinical determinants of extraintestinalmedRxiv : the preprint server for health sciences · 2026Article
- Toxin gene profiles, antibiotic resistance, and genetic diversity ofCurrent research in food science · 2026Article
- Genetic characterization of gut-associatedFrontiers in microbiology · 2026Article
- Sporulation Abilities and Heat Resistance ofFoods (Basel, Switzerland) · 2025Article
- Insights into the utilisation of 1,2-propanediol and interactions with the cell envelope of Clostridium perfringens.Gut pathogens · 2025Article
- Comparative genomic analysis of food-animal-derived and human-derivedFrontiers in microbiology · 2025Article
- First genomic analysis of aFrontiers in microbiology · 2025Article
- Isolation of a VirulentCurrent issues in molecular biology · 2024Article
- Identification of a newFrontiers in microbiology · 2024Article
- Types A and FApplied and environmental microbiology · 2023Article
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- Extensive genome analysis identifies novel plasmid families inMicrobial genomics · 2023Article
- Molecular characteristics and phylogenetic analysis ofFrontiers in microbiology · 2023Article
- Battling Enteropathogenic Clostridia: Phage Therapy forFrontiers in microbiology · 2022Review
- Intra-species diversity ofFrontiers in microbiology · 2022Article
- Establishment of a Publicly Available Core Genome Multilocus Sequence Typing Scheme for Clostridium perfringens.Microbiology spectrum · 2021Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clostridium perfringens causes a plethora of devastating infections, with toxin production being the underlying mechanism of pathogenicity in various hosts. Genomic analyses of 206 public-available C. perfringens strains´ sequence data identified a substantial degree of genomic variability in respect to episome content, chromosome size and mobile elements. However, the position and order of the local collinear blocks on the chromosome showed a considerable degree of preservation. The strains were divided into five stable phylogroups (I-V). Phylogroup I contained human food poisoning strains with chromosomal enterotoxin (cpe) and a Darmbrand strain characterized by a high frequency of mobile elements, a relatively small genome size and a marked loss of chromosomal genes, including loss of genes encoding virulence traits. These features might correspond to the adaptation of these strains to a particular habitat, causing human foodborne illnesses. This contrasts strains that belong to phylogroup II where the genome size points to the acquisition of genetic material. Most strains of phylogroup II have been isolated from enteric lesions in horses and dogs. Phylogroups III, IV and V are heterogeneous groups containing a variety of different strains, with phylogroup III being the most abundant (65.5%). In conclusion, C. perfringens displays five stable phylogroups reflecting different disease involvements, prompting further studies on the evolution of this highly important pathogen.
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