ArticleScientific reports2021
A spiking neural network (SNN) for detecting high frequency oscillations (HFOs) in the intraoperative ECoG.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between Removal of High-Frequency Oscillations and the Effect of Epilepsy Surgery: A Meta-Analysis.Journal of neurological surgery. Part A, Central European neurosurgery · 2024Pooled it
- Article
- Advancing neuroengineering with Neuromorphic Twins.Nature communications · 2026Review
- NEuroMOrphic Neural-Response Decoding System for Adaptive and Personalized Neuro-Prosthetics' Control.Biomimetics (Basel, Switzerland) · 2025Article
- A neuromorphic multi-scale approach for real-time heart rate and state detection.Npj unconventional computing · 2025Article
- Using high-frequency oscillations from brief intraoperative neural recordings to predict the seizure onset zone.Communications medicine · 2024Article
- A tunable multi-timescale Indium-Gallium-Zinc-Oxide thin-film transistor neuron towards hybrid solutions for spiking neuromorphic applications.Communications engineering · 2024Article
- A real-time HFO detection framework for localization of SOZ in iEEG recording of patients with epilepsy.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Robust compression and detection of epileptiform patterns in ECoG using a real-time spiking neural network hardware framework.Nature communications · 2024Article
- Networks through the lens of high-frequency oscillations.Frontiers in network physiology · 2024Review
- Suppressive effects of a transient receptor potential melastatin 8 (TRPM8) agonist on hyperthermia-induced febrile seizures in infant mice.Frontiers in pharmacology · 2023Article
- High-Frequency Oscillations and Epileptogenic Network.Current neuropharmacology · 2022Article
- A neuromorphic spiking neural network detects epileptic high frequency oscillations in the scalp EEG.Scientific reports · 2022Article
- Automatic Detection of High-Frequency Oscillations With Neuromorphic Spiking Neural Networks.Frontiers in neuroscience · 2022Review
- An electronic neuromorphic system for real-time detection of high frequency oscillations (HFO) in intracranial EEG.Nature communications · 2021Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To achieve seizure freedom, epilepsy surgery requires the complete resection of the epileptogenic brain tissue. In intraoperative electrocorticography (ECoG) recordings, high frequency oscillations (HFOs) generated by epileptogenic tissue can be used to tailor the resection margin. However, automatic detection of HFOs in real-time remains an open challenge. Here we present a spiking neural network (SNN) for automatic HFO detection that is optimally suited for neuromorphic hardware implementation. We trained the SNN to detect HFO signals measured from intraoperative ECoG on-line, using an independently labeled dataset (58 min, 16 recordings). We targeted the detection of HFOs in the fast ripple frequency range (250-500 Hz) and compared the network results with the labeled HFO data. We endowed the SNN with a novel artifact rejection mechanism to suppress sharp transients and demonstrate its effectiveness on the ECoG dataset. The HFO rates (median 6.6 HFO/min in pre-resection recordings) detected by this SNN are comparable to those published in the dataset (Spearman's [Formula: see text] = 0.81). The postsurgical seizure outcome was "predicted" with 100% (CI [63 100%]) accuracy for all 8 patients. These results provide a further step towards the construction of a real-time portable battery-operated HFO detection system that can be used during epilepsy surgery to guide the resection of the epileptogenic zone.
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