ArticleEuropean endodontic journal2021
The Structural, Physical, and In Vitro Biological Performance of Freshly Mixed and Set Endodontic Sealers.
Article in European endodontic journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Rheological Properties of Nine Commercially Available Endodontic Sealers by Substrate and Temperature: A Comparative In Vitro Study.Journal of functional biomaterials · 2026Article
- Cytotoxicity of Root Canal Sealers and Potential Clinical Implications: A Comprehensive Systematic Review of In Vitro Studies.Journal of clinical medicine · 2026Review
- Article
- Effect of heat application on the physicochemical properties of new endodontic sealers: an in vitro and SEM study.Odontology · 2024Article
- Effect of Foraminal Enlargement on Periapical Healing in Necrotic Teeth: A Systematic Review.Iranian endodontic journal · 2024Review
- Article
- Medical and Dental Applications of Titania Nanoparticles: An Overview.Nanomaterials (Basel, Switzerland) · 2022Review
- Effect of Currently Available Nanoparticle Synthesis Routes on Their Biocompatibility with Fibroblast Cell Lines.Molecules (Basel, Switzerland) · 2022Article
- Synthesis and Characterization of Titanium Oxide Nanoparticles with a Novel Biogenic Process for Dental Application.Nanomaterials (Basel, Switzerland) · 2022Article
- An Updated Review on Properties and Indications of Calcium Silicate-Based Cements in Endodontic Therapy.International journal of dentistry · 2022Review
- The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application.BioMed research international · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to evaluate the in vitro performance of endodontic sealers in their freshly mixed and set forms.
methodsThe commercially used endodontic sealers (AH Plus, Dia-ProSeal, GuttaFlow 2, and Pulpdent Root Canal Sealer) were investigated and the chemical structure of freshly mixed and set sealers were assessed with Fourier transform infrared spectroscopy (FTIR). The surface morphology and elemental analysis were assessed with a scanning electron microscope (SEM) equipped with energy-dispersive X-ray spectroscopy. The pH and solubility analysis were performed and the cytotoxicity was done on extracts of freshly mixed and set materials using Alamar blue assay. One way ANOVA and Post Hoc Tukey analysis was used to do multiple comparison analysis of the mean values and standard deviation results through SPSS version 20 (IBM Software, NY, USA) for pH, solubility, and cytotoxicity analysis.
resultsFTIR analysis revealed the structural pattern and the difference in freshly mixed and set samples was observed with the change in intensities of the peaks. The morphological pattern revealed the presence of micro/nano-particles with pores distributed throughout their structure. The sealer with the least solubility was AH Plus (0.10±0.01) followed by Dia-ProSeal (0.77±0.25), GuttaFlow 2 (1.88±0.82) and Pulpdent Root Canal Sealer (3.03±0.18). The solubility of AH plus was significantly lower (P<0.05) in comparison to GuttaFlow 2 and Pulpdent Root Canal Sealer. The highest pH (10.09±0.034) in the freshly mixed state and highest cytotoxicity in the freshly mixed (70.08±5.852) and set sealers (83.87±5.409) (P<0.05) at day 7 was observed in Dia-ProSeal. GuttaFlow 2 was the most biocompatible sealer in the set state and AH Plus was the most biocompatible sealer in the freshly mixed state at day 7.
conclusionClinically, the sealer is applied in fresh state, whereby this study signifies that which material is more biocompatible in fresh state and provides insight information to clinicians. AH Plus showed least solubility and cytocompatibility in fresh state compared to other groups.
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