ArticleScience translational medicine2021
Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- Rationalizing Heterogeneity in Staphylococcus aureus Bacteremia: Current Progress and Future Goals.The Journal of infectious diseases · 2026Review
- Hematopoietic Aging and Leukemia: Mechanistic and Therapeutic Insights.International journal of molecular sciences · 2026Review
- The glycan fingerprint in immune thrombocytopenia.Research and practice in thrombosis and haemostasis · 2026Article
- Induced pluripotent stem cell-derived platelets kill multidrug-resistantResearch and practice in thrombosis and haemostasis · 2026Article
- Is there a role for anticoagulation with dabigatran in S. aureus bacteremia? Protocol for the adjunctive treatment domain of theBMJ open · 2025Article
- Drug Repurposing: An Emerging Strategy inJournal of microbiology and biotechnology · 2025Review
- Platelets and mortality in bloodstream infection: a multicenter cohort study.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2025Article
- The Susceptibility Profiles of Human Peripheral Blood Cells toMicroorganisms · 2025Review
- Enhanced Killing of Methicillin-Resistant Staphylococcus aureus With Ceftaroline or Vancomycin in Combination With Carbapenems.The Journal of infectious diseases · 2025Article
- Mrc1 (MMR, CD206) controls the blood proteome in reducing inflammation, age-associated organ dysfunction and mortality in sepsis.Nature communications · 2025Article
- Repurposing Diflunisal as an Antivirulence Agent AgainstInfectious microbes & diseases · 2025Article
- Multi-omic signatures of host response associated with presence, type, and outcome of enterococcal bacteremia.mSystems · 2025Article
- Article
- Platelet P2YBritish journal of pharmacology · 2024Review
- Endothelial ADAM10 utilization defines a molecular pathway of vascular injury in mice with bacterial sepsis.The Journal of clinical investigation · 2023Article
- Protective Effect of Ticagrelor Against Infective Endocarditis Induced by VirulentJACC. Basic to translational science · 2023Article
- Systematic analysis of drug combinations against Gram-positive bacteria.Nature microbiology · 2023Article
- Machine Learning with Alpha Toxin Phenotype to Predict Clinical Outcome in Patients withToxins · 2023Article
- Prognostic significance of early platelet dynamics in Staphylococcus aureus bacteremia.BMC infectious diseases · 2023Article
- Novel evidence on sepsis-inducing pathogens: from laboratory to bedside.Frontiers in microbiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 1 country.
Josh SunBiomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-7854-2633
Satoshi UchiyamaBiomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-0979-7998
Joshua OlsonBiomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
Yosuke MorodomiDepartment of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, Scripps Research, La Jolla, CA 92037, USA.
Ingrid CornaxBiomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
Nao AndoBiomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
Yohei KohnoBiomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
May M T KyawBiomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
Bernice AguilarBiomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-0643-7460
Nina M HasteBiomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-4752-2714
Sachiko KanajiDepartment of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, Scripps Research, La Jolla, CA 92037, USA.
Taisuke KanajiDepartment of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, Scripps Research, La Jolla, CA 92037, USA.
Warren E RoseSchool of Pharmacy, University of Wisconsin, Madison, WI 53705, USA.ORCID 0000-0001-5012-5993
George SakoulasDepartment of Pediatrics, UC San Diego, La Jolla, CA 92093, USA.
Jamey D MarthCenter for Nanomedicine, UC Santa Barbara, Santa Barbara, CA 93106, USA.
Victor NizetBiomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA. vnizet@health.ucsd.edu.ORCID 0000-0003-3847-0422
University of California San Diego · USScripps Research Institute · USUniversity of California, Santa Barbara · USUniversity of Wisconsin–Madison · US
Funding
Protein Glycosylation in the Coagulopathy and Inflammation of SepsisP01HL131474 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MARTH, JAMEY · 2016 to 2025
$26.2MSiglec Modulation of Inflammatory ResponsesP01HL107150 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LE, DZUNG T · 2011 to 2017
$18.0MGlycoprotein Remodeling in the Vasculopathy and Coagulopathy of SepsisR01HL125352 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MARTH, JAMEY, NIZET, VICTOR · 2014 to 2018
$3.6MSafety and Dose Optimization of High-Dose Anakinra in Kawasaki DiseaseU54HD090259 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CAPPARELLI, EDMUND VINCENT, NIZET, VICTOR · 2016 to 2018
$2.2MMechanisms and use of penicillin-binding protein inhibition to optimize cationic peptide anti-MRSA treatmentR01AI132627 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ROSE, WARREN E · 2017 to 2021
$2.1MUCSD Research Training Program for VeterinariansT32OD017863 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ERNST, PETER B., SIGURDSON, CHRISTINA · 2014 to 2023
$2.0MSafety and Dose Optimization of High-Dose Anakinra in Kawasaki DiseaseP50HD090259 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CAPPARELLI, EDMUND VINCENT, NIZET, VICTOR · 2019 to 2020
$1.4MGlycan-Lectin Receptor Regulation of Macrophage Maturation and Lung InnateDefenses in the Fetus and Newborn InfantR01AI142864 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR, PRINCE, LAWRENCE S · 2019 to 2021
$1.2MMechanisms of human pre-B cell differentiationR21AI124326 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI GEORGOPOULOS, KATIA · 2016 to 2017
$450kNHLBI NIH HHS P01 HL107150NHLBI NIH HHS P01 HL131474NHLBI NIH HHS R01 HL125352NIAID NIH HHS R01 AI132627NIAID NIH HHS R01 AI142864NIAID NIH HHS R21 AI124326NICHD NIH HHS P50 HD090259NICHD NIH HHS U54 HD090259NIH HHS T32 OD017863
Abstract
PubMed holds no abstract for this paper.
Indexed as
BacteremiaPharmaceutical PreparationsStaphylococcal InfectionsAnimalsBlood PlateletsHumansMiceStaphylococcus aureusPharmaceutical Preparations
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.