ArticleNeurology2021
Baseline Blood-Brain Barrier Leakage and Longitudinal Microstructural Tissue Damage in the Periphery of White Matter Hyperintensities.
Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Imaging-validated correlates and implications of the pathophysiologic mechanisms of ageing-related cerebral large artery and small vessel diseases: a systematic review and meta-analysis.Behavioral and brain functions : BBF · 2025Pooled it
- Blood-brain barrier disruption and increased free water are associated with worse cognitive performance in patients with chronic cerebrovascular disease.NeuroImage. Clinical · 2024Trial
- DCE-MRI study on regional and Fazekas-stratified heterogeneity of blood-brain barrier leakage in white matter hyperintensities and related risk factors.Quantitative imaging in medicine and surgery · 2026Article
- Ischemic stroke: molecular mechanisms of blood-brain barrier dysfunction and opportunities for drug development.Fluids and barriers of the CNS · 2026Review
- White Matter Hyperintensity Burden and Short-Interval Change Associated With Sleep Apnoea in the UK Biobank.Annals of clinical and translational neurology · 2026Article
- Microglial reactivity predicts hippocampal, but not global, atrophy in cerebral small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions.Nature communications · 2026Article
- Multimodal Magnetic Resonance Imaging Signatures of White Matter Hyperintensities: Mechanistic Insights Into Pathobiological Heterogeneity.Journal of stroke · 2026Review
- Longitudinal biomarker studies in human neuroimaging: capturing biological change of Alzheimer's pathology.Alzheimer's research & therapy · 2025Review
- Mechanistic Interplay of Gut Microbiota and Blood-Brain Barrier Integrity in Neurodegenerative Diseases.Molecular neurobiology · 2025Review
- Relationships between multimodal ocular imaging and white matter hyperintensity volume.Quantitative imaging in medicine and surgery · 2025Article
- MRI signatures associated with active ischemia and disease severity in cerebral small vessel disease.Neuroimage. Reports · 2025Article
- Myelin basic protein and occludin may be the biomarkers to diagnose leukoaraiosis and cognitive dysfunction.Scientific reports · 2025Article
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- Free Water-Corrected Fractional Anisotropy in Normal-Appearing White Matter as a Potential Neuroimaging Biomarker for Attention and Executive Function Impairment in Cerebral Small Vessel Disease.CNS neuroscience & therapeutics · 2025Article
- Microstructural and microvascular features of white matter hyperintensities and their association with small vessel disease markers.Scientific reports · 2025Article
- Blood-brain barrier integrity disruption is associated with both chronic vascular risk factors and white matter hyperintensities.The journal of prevention of Alzheimer's disease · 2025Article
- Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health.GeroScience · 2025Review
- Analysis of the impact of cerebral small vessel disease on neurological outcomes in patients with basal ganglia/corona radiata ischemic stroke treated with intravenous thrombolysis under multimodal MRI guidance.Frontiers in neurology · 2025Article
- A window into the brain: multimodal MRI assessment of vascular cognitive impairment.Frontiers in neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the 2-year change in parenchymal diffusivity, a quantitative marker of microstructural tissue condition, and the relationship with baseline blood-brain barrier (BBB) permeability, in tissue at risk, i.e., the perilesional zone surrounding white matter hyperintensities (WMH) in patients with cerebral small vessel disease (cSVD).
methodsPatients with sporadic cSVD (lacunar stroke or mild vascular cognitive impairment) underwent 3T MRI at baseline, including dynamic contrast-enhanced MRI to quantify BBB permeability (i.e., leakage volume and rate) and intravoxel incoherent motion imaging (IVIM), a diffusion technique that provides parenchymal diffusivity
resultsWe analyzed 43 patients (age 68 ± 12 years, 58% male). In the perilesional zones, ∆
conclusionBBB leakage at baseline is related to the 2-year change in parenchymal diffusivity in the perilesional zone of WMH. These results support the hypothesis that BBB impairment might play an early role in subsequent microstructural white matter degeneration as part of the pathophysiology of cSVD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.