Evidence map›Paper›PMID 33762416›Full record

ArticleJournal of virology2021

MAGI-1 PDZ2 Domain Blockade Averts Adenovirus Infection via Enhanced Proteolysis of the Apical Coxsackievirus and Adenovirus Receptor.

Mahmoud S Alghamri, Priyanka Sharma, Timothy L Williamson, James M Readler, Ran Yan, S Dean Rider, Heather A Hostetler, David R Cool, Abimbola O Kolawole, Katherine J D A Excoffon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mahmoud S AlghamriDepartment of Biological Sciences, Wright State University, Dayton, Ohio, USA.
Priyanka SharmaDepartment of Biological Sciences, Wright State University, Dayton, Ohio, USA.
Timothy L WilliamsonDepartment of Biological Sciences, Wright State University, Dayton, Ohio, USA.
James M ReadlerDepartment of Biological Sciences, Wright State University, Dayton, Ohio, USA.
Ran YanDepartment of Biological Sciences, Wright State University, Dayton, Ohio, USA.
S Dean RiderDepartment of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio, USA.
Heather A HostetlerDepartment of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio, USA.
David R CoolDepartment of Pharmacology and Toxicology, Wright State University, Dayton, Ohio, USA.
Abimbola O KolawoleDepartment of Biological Sciences, Wright State University, Dayton, Ohio, USA.
Katherine J D A ExcoffonDepartment of Biological Sciences, Wright State University, Dayton, Ohio, USA.
Wright State University · US

Funding

Prevention of adenovirus pathogenesis through downregulation of the apical adenovirus receptorR01AI127816 · NIAID · WRIGHT STATE UNIVERSITY · PI KOLAWOLE, ABIMBOLA OLAYINKA · 2017 to 2021
$1.9M
The role of long chain acyl-CoAs in nuclear receptor regulationR00DK077573 · NIDDK · WRIGHT STATE UNIVERSITY · PI HOSTETLER, HEATHER A · 2009 to 2011
$747k
NIAID NIH HHS R01 AI127816NIDDK NIH HHS R00 DK077573
6 · The paper itself

Abstract

Adenoviruses (AdVs) are etiological agents of gastrointestinal, heart, eye, and respiratory tract infections that can be lethal for immunosuppressed people. Many AdVs use the coxsackievirus and adenovirus receptor (CAR) as a primary receptor. The CAR isoform resulting from alternative splicing that includes the eighth exon, CAR

Indexed as

3T3 CellsADAM17 ProteinAdaptor Proteins, Signal TransducingAdenoviridaeAdenoviridae InfectionsAmyloid Precursor Protein SecretasesAnimalsCell Adhesion MoleculesCoxsackie and Adenovirus Receptor-Like Membrane ProteinDogsGuanylate KinasesHEK293 CellsHumansMadin Darby Canine Kidney CellsMiceProtein DomainsADAM17 ProteinAdaptor Proteins, Signal TransducingAmyloid Precursor Protein SecretasesCell Adhesion MoleculesCLMP protein, humanCoxsackie and Adenovirus Receptor-Like Membrane ProteinGuanylate KinasesMAGI1 protein, humanADAM17adenoviruscell-penetrating peptideepithelial cellsgamma-secretaseMAGI-1PDZ domain

Identifiers

PMID33762416
PMCPMC8437357
OpenAlexW3139502807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.