Evidence map›Paper›PMID 33762408›Full record

ArticleJournal of virology2021

Evaluation of HIV-1 latency reversal and antibody-dependent viral clearance by quantification of singly spliced HIV-1

Hongbo Gao, Ayşe N Ozantürk, Qiankun Wang, Gray H Harlan, Aaron J Schmitz, Rachel M Presti, Kai Deng, Liang Shan

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Sex Differences in Human Immunodeficiency Virus Persistence and Reservoir Size During Aging.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Hongbo GaoInstitute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Ayşe N OzantürkDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Qiankun WangDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Gray H HarlanDepartment of Chemistry, Washington University, St Louis, MO, USA.
Aaron J SchmitzDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Rachel M PrestiDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Kai DengInstitute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China dengkai6@mail.sysu.edu.cn liang.shan@wustl.edu.ORCID https://orcid.org/0000-0002-9973-8130
Liang ShanDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA dengkai6@mail.sysu.edu.cn liang.shan@wustl.edu.ORCID https://orcid.org/0000-0002-8833-2514
Washington University in St. Louis · USSun Yat-sen University · CN

Funding

A novel PCR-based method for quantification of antibody-dependent clearance of HIV-1 reservoirsR21AI150418 · NIAID · WASHINGTON UNIVERSITY · PI SHAN, LIANG · 2020 to 2021
$433k
NIAID NIH HHS R21 AI150418
6 · The paper itself

Abstract

The latent reservoir of HIV-1 is a major barrier for viral eradication. Potent HIV-1 broadly neutralizing antibodies (bNabs) have been used to prevent and treat HIV-1 infections in animal models and clinical trials. Combination of bNabs and latency-reversing agents (LRAs) is considered a promising approach for HIV-1 eradication. PCR-based assays that can rapidly and specifically measure singly spliced HIV-1

Identifiers

PMID33762408
PMCPMC8139706
OpenAlexW3136205605

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.