ReviewClinical medicine (London, England)2021
Iron deficiency without anaemia: a diagnosis that matters.
Review in Clinical medicine (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06276140 (Preoperative Evaluation and Impact of Iron Deficiency Anaemia on the Incidence of Perioperative Complications and Quality of Recovery After Radical Colorectal Cancer Surgery), which is not on this map. Cited by 90 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preoperative Evaluation and Impact of Iron Deficiency Anaemia on the Incidence of Perioperative Complications and Quality of Recovery After Radical Colorectal Cancer Surgery
Who cites it
90 citing papers in PubMed, 3 syntheses or guidelines pooled it, 176 citations in OpenAlex.
- What is the impact of whole-blood donation frequency on donor health? A systematic review.Vox sanguinis · 2026Pooled it
- The benefits and harms of oral iron supplementation in non-anaemic pregnant women: a systematic review and meta-analysis.Family practice · 2025Pooled it
- Preoperative iron supplementation in non-anemic patients undergoing major surgery: a systematic review and meta-analysis.Brazilian journal of anesthesiology (Elsevier)Pooled it
- Energy restriction and iron supplementation improve iron status in women with obesity regardless of red meat consumption: a randomized controlled trial.Scientific reports · 2026Trial
- Maternal Adiposity and Inflammation: Risk Factors for Iron Deficiency in Pregnancy.The Journal of nutrition · 2025Trial
- Electrochemical differentiation of native-denatured hemoglobin using a same-metal PCB-based three-electrode system.RSC advances · 2026Article
- Association Between Iron Availability and Accelerated Biological Aging in Non-Anemic Women of Reproductive Age: A Nationally Representative Cross-Sectional Study.Biological trace element research · 2026Article
- Suspected Seronegative Spondyloarthropathy in a Young Woman With Ulcerative Colitis and Concurrent Bleeding Symptoms.Cureus · 2026Article
- Variation in antenatal anaemia guidelines across the NHS in the United Kingdom: A cross-sectional study.British journal of haematology · 2026Article
- Iron Deficiency Anemia in Female Adolescents: An Epidemiological Study From Eastern Iran-A Cross-Sectional Study.Health science reports · 2026Article
- Ferritin as a diagnostic point-of-care marker in iron deficiency anemia: a narrative review and clinical implications.Annals of translational medicine · 2026Review
- Preoperative Hemoglobin Threshold as a Predictor of Transfusion Risk in Pregnant Patients: An Observational Study for Informing Patient Blood Management Strategies in a Tertiary Care Facility in Romania.Medicina (Kaunas, Lithuania) · 2026Observational
- Navigating Anemia in Solid and Hematologic Malignancies: A Comprehensive Review of Classical and Emerging Therapies.European journal of haematology · 2026Review
- New-Onset Acute Heart Failure With Reduced Ejection Fraction Associated With Severe Microcytic Anemia.Clinical case reports · 2026Article
- Physiologically based ferritin thresholds to redefine early pregnancy iron screening: a cross-sectional study.Scientific reports · 2026Article
- Prospective Associations of Serum Vitamin B12, Homocysteine, and Ferritin Levels with Probable Sarcopenia.Nutrients · 2026Article
- [Recent advances in the management of iron deficiency and iron deficiency anemia during pregnancy].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2026Review
- Iron deficiency and dementia risk: evidence from the Swedish population-based cohort study AMORIS.BMC medicine · 2026Article
- The Prevalence of Anemia and Diagnostic Usefulness of Ferritin and Hepcidin in Antiphospholipid Syndrome and Systemic Lupus Erythematosus Patients.Diseases (Basel, Switzerland) · 2026Article
- Iron Deficiency in Pulmonary Hypertension-Prevalence, Impact on Prognosis and Disease Burden in Pulmonary Arterial Hypertension and Pulmonary Hypertension Related to Hypoxia: A Review.International journal of molecular sciences · 2026Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron deficiency anaemia (IDA) currently affects 1.2 billion people and iron deficiency without anaemia (IDWA) is at least twice as common. IDWA is poorly recognised by clinicians despite its high prevalence, probably because of suboptimal screening recommendations. Diagnosing IDWA relies on a combination of tests, including haemoglobin and ferritin levels, as well as transferrin saturation. Although the causes of iron deficiency may sometimes be obvious, many tend to be overlooked. Iron sufficiency throughout pregnancy is necessary for maternal and foetal health. Preoperative IDWA must be corrected to reduce the risk of transfusion and postoperative anaemia. Oral iron is the first-line treatment for managing IDWA; however, intravenous supplementation should be used in chronic inflammatory conditions and when oral therapy is poorly tolerated or ineffective. This review considers the causes and clinical features of IDWA, calls for greater awareness of the condition, and proposes diagnostic and management algorithms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.