Evidence map›Paper›PMID 33762366›Full record

ArticleClinical medicine (London, England)2021

Subarachnoid haemorrhage rules in the decision for acute CT of the head: external validation in a UK cohort.

Robert W Foley, Sanjeev Ramachandran, Abisoye Akintimehin, Samuel Williams, Steve J Connor, Jonathan Hart, Yasmin K Kapadia, Ivan Timofeev, Christos M Tolias, Martin B Whyte and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Clinical medicine (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. High risk and low incidence diseases: Aneurysmal subarachnoid hemorrhage.The American journal of emergency medicine · 2025
    Review
  2. Article
  3. Subarachnoid haemorrhage rules.Clinical medicine (London, England) · 2021
    Article
  4. Response.Clinical medicine (London, England) · 2021
    Article
  5. Assisting clinical decision making: tools, rules and teams.Clinical medicine (London, England) · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Robert W FoleyKing's College Hospital NHS Foundation Trust, London, UK, Addenbrooke's Hospital, Cambridge, UK and University Hospitals Bristol NHS Foundation Trust, Bristol, UK; robertfoley@nhs.net.
Sanjeev RamachandranAddenbrooke's Hospital, Cambridge, UK.
Abisoye AkintimehinKing's College Hospital NHS Foundation Trust, London, UK.
Samuel WilliamsKing's College Hospital NHS Foundation Trust, London, UK.
Steve J ConnorKing's College Hospital NHS Foundation Trust, London, UK.
Jonathan HartKing's College Hospital NHS Foundation Trust, London, UK.
Yasmin K KapadiaKing's College Hospital NHS Foundation Trust, London, UK.
Ivan TimofeevAddenbrooke's Hospital, Cambridge, UK.
Christos M ToliasKing's College Hospital NHS Foundation Trust, London, UK.
Martin B WhyteKing's College Hospital NHS Foundation Trust, London, UK.
Philip A KellyKing's College Hospital NHS Foundation Trust, London, UK.
King's College Hospital NHS Foundation Trust · GBAddenbrooke's Hospital · GBUniversity Hospitals Bristol NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Ottawa subarachnoid haemorrhage (SAH) rule and the Emerald SAH rule are clinical decision tools to aid in the decision for computed tomography (CT) of the head in patients attending an emergency department (ED) with acute non-traumatic headache. The objective of this study was to analyse the performance of these rules in a contemporary UK cohort.

methodsWe performed a retrospective external validation study. Patients undergoing CT of the head for the evaluation and treatment of non-traumatic headaches over a 6-month period in the ED at two tertiary centres were assessed. Each patient's Ottawa rule and Emerald rule were calculated and compared with their final diagnosis.

resultsThe cohort consisted of 366 patients and there were 16 cases of SAH (based on CT findings or the presence of xanthochromia in cerebrospinal fluid). The Ottawa rule identified 288 patients requiring CT of the head. The sensitivity of the Ottawa rule was 100% (95% confidence interval (CI) 71-100%) and the specificity was 22% (95% CI 18-27%). The Emerald rule identified 267 patients who required CT, and achieved a sensitivity of 81% (95% CI 54-96%) and a specificity of 27% (95% CI 23-32%).

conclusionsThe Ottawa SAH rule correctly identified all patients with SAH in this contemporary cohort. The Emerald rule did not perform as well in this cohort and is unsuitable for clinical use. The Ottawa rule is a useful tool to aid in the decision for CT of the head in patients presenting with acute non-traumatic headache to the ED.

Indexed as

Subarachnoid HemorrhageEmergency Service, HospitalHeadHumansRetrospective StudiesSensitivity and SpecificityTomography, X-Ray ComputedUnited Kingdomclinical decision toolemergency departmentheadacheimagingsubarachnoid haemorrhage

Identifiers

PMID33762366
PMCPMC8002795
OpenAlexW3136509462

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.