Evidence map›Paper›PMID 33762299›Full record

ArticleJournal of medical ethics2022

Future of global regulation of human genome editing: a South African perspective on the WHO Draft Governance Framework on Human Genome Editing.

Bonginkosi Shozi, Tamanda Kamwendo, Julian Kinderlerer, Donrich W Thaldar, Beverley Townsend, Marietjie Botes

Abstract read
In one paragraph

Article in Journal of medical ethics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Bonginkosi ShoziSchool of Law, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa 214511633@stu.ukzn.ac.za.ORCID 0000-0003-2994-0795
Tamanda KamwendoSchool of Law, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.ORCID 0000-0002-5434-113X
Julian KinderlererSchool of Law, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.ORCID 0000-0003-0481-0441
Donrich W ThaldarSchool of Law, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.ORCID 0000-0002-7346-3490
Beverley TownsendSchool of Law, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.ORCID 0000-0002-8486-6041
Marietjie BotesSchool of Law, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.ORCID 0000-0002-6613-6977

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

WHO in 2019 established the Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing, which has recently published a Draft Governance Framework on Human Genome Editing. Although the Draft Framework is a good point of departure, there are four areas of concern: first, it does not sufficiently address issues related to establishing safety and efficacy. Second, issues that are a source of tension between global standard setting and state sovereignty need to be addressed in a more nuanced fashion. Third, it fails to meaningfully engage with the extent to which the conceptualisation of human dignity may justifiably vary between jurisdictions. Fourth, the meaning of harm to the interests of a future person requires clarity. Provided these four areas of concern can be addressed, the future of the global governance of human genome editing may hold promise.

Indexed as

Gene EditingGenome, HumanHumansRespectSouth AfricaWorld Health Organizationautonomygenethicsgenetic engineeringhuman dignitylaw

Identifiers

PMID33762299
PMCPMC8899489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.