Evidence map›Paper›PMID 33762245›Full record

ArticleBMJ open2021

MUK

Sarah Brown, Debbie Sherratt, Samantha Hinsley, Louise Flanagan, Sadie Roberts, Katrina Walker, Andrew Hall, Guy Pratt, Christina Messiou, Matthew Jenner and 2 more

Abstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Trial
  2. How to approach the high-risk myeloma from induction through relapse?Hematology. American Society of Hematology. Education Program · 2025
    Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sarah Brown *Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK S.Brown@leeds.ac.uk martin.kaiser@icr.ac.uk.ORCID http://orcid.org/0000-0002-7975-7537
Debbie Sherratt *Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Samantha HinsleyClinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Louise FlanaganClinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Sadie RobertsClinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Katrina WalkerClinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Andrew HallClinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Guy PrattCentre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK.
Christina MessiouCentre for Myeloma Research, Institute of Cancer Research, London, UK.
Matthew Jenner *Department of Haematology, Southampton General Hospital, Southampton, UK.
Martin Kaiser *Centre for Myeloma Research, Institute of Cancer Research, London, UK S.Brown@leeds.ac.uk martin.kaiser@icr.ac.uk.
Myeloma UK Early Phase Clinical Trial Network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMultiple myeloma (MM) is a plasma cell tumour with over 5800 new cases each year in the UK. The introduction of biological therapies has improved outcomes for the majority of patients with MM, but in approximately 20% of patients the tumour is characterised by genetic changes which confer a significantly poorer prognosis, generally termed high-risk (HR) MM. It is important to diagnose these genetic changes early and identify more effective first-line treatment options for these patients. METHODS AND ANALYSIS: The Myeloma UK ETHICS AND DISSEMINATION: Ethics approval London South East Research Ethics Committee (Ref: 17/LO/0022, 17/LO/0023). Results of studies will be submitted for publication in a peer-reviewed journal. TRIAL REGISTRATION NUMBER: ISRCTN16847817, May 2017; Pre-results.

Indexed as

Hematopoietic Stem Cell TransplantationLeukemia, Plasma CellMultiple MyelomaAntineoplastic Combined Chemotherapy ProtocolsBayes TheoremClinical Trials, Phase II as TopicCohort StudiesDexamethasoneHumansLondonMulticenter Studies as TopicQuality of LifeTransplantation, AutologousDexamethasoneclinical trialsmyelomastatistics & research methods

Identifiers

PMID33762245
PMCPMC7993167

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.