ReviewTrials2021
The time is now: role of pragmatic clinical trials in guiding response to global pandemics.
Review in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A rapid review of community engagement and informed consent processes for adaptive platform trials and alternative design trials for public health emergencies.Wellcome open research · 2023Pooled it
- Intraoperative Esketamine and Postpartum Depression Among Women With Cesarean Delivery: A Randomized Clinical Trial.JAMA network open · 2025Trial
- The future is now: our experience starting a remote clinical trial during the beginning of the COVID-19 pandemic.Trials · 2021Trial
- A REDCap advanced randomization module to meet the needs of modern trials.Journal of biomedical informatics · 2025Article
- Effectiveness of electronic medical record-based strategies for death and hospital admission endpoint capture in pragmatic clinical trials.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Coronavirus Disease 2019 (COVID-19) Real World Data Infrastructure: A Big-Data Resource for Study of the Impact of COVID-19 in Patient Populations With Immunocompromising Conditions.Open forum infectious diseases · 2025Article
- Comparison of the Latin America Regulation Landscape and International Reference Health Authorities to Hasten Drug Registration and Clinical Research Applications.Therapeutic innovation & regulatory science · 2023Article
- Impact of COVID-19 pandemic on nonpharmacological pain management trials in military and veteran healthcare settings: an evaluation informed by implementation science.Translational behavioral medicine · 2023Article
- Digital health-high tech or high touch?Wiener medizinische Wochenschrift (1946) · 2023Article
- Comparing In-Person Only, Telemedicine Only, and Hybrid Health Care Visits Among Older Adults in Safety-Net Clinics.Telemedicine reports · 2023Article
- Clinical research methodology process: what has changed with COVID-19?European heart journal supplements : journal of the European Society of Cardiology · 2022Article
- Data capture and sharing in the COVID-19 pandemic: a cause for concern.The Lancet. Digital health · 2022Review
- Mapping ongoing nutrition intervention trials in muscle, sarcopenia, and cachexia: a scoping review of future research.Journal of cachexia, sarcopenia and muscle · 2022Article
- Health science research barriers and facilitators in the midst of the COVID-19 crisis: scoping reviewRevista colombiana de obstetricia y ginecologia · 2021Article
- Clinical research methodology process: what is changing with COVID-19?European heart journal supplements : journal of the European Society of Cardiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Along with its heavy toll of morbidity and mortality, the coronavirus disease 2019 (COVID-19) pandemic exposed several limitations of the current global research response. The slow and inefficient process of carrying out traditional randomized clinical trials led regulatory authorities to hastily approve treatments and tests without sufficient evidence of safety and efficacy.We here outline issues with the current research platform, summarize shortcomings of traditional randomized clinical trials particularly apparent at the time of pandemics, and highlight the advantages of pragmatic clinical trials as an alternative to rapidly generate the needed clinical evidence. We further discuss barriers and challenges to pragmatic clinical trials implementation and explore opportunities for research institutions and regulatory authorities to facilitate widespread adoption of this vital research tool.As a subsequent wave of COVID-19, and/or another epidemic, are all but inevitable in our lifetime, we must ensure that our research infrastructure is conducive to carrying out pragmatic clinical trials to expeditiously generate the needed evidence and blunt the epidemic's toll on human lives and livelihoods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.